obsolete intraductal papillary adenocarcinoma with invasion

Invasive Papillary Carcinoma (IPC) - A Rare Form of Breast Cancer

Invasive papillary carcinoma (IPC) is a rare and aggressive form of breast cancer that accounts for less than 1-2% of newly diagnosed cases of invasive breast cancer [11][12]. It is characterized by the presence of papillary structures in more than 90% of its invasive components [7].

Histological Features

The histologic features of IPC include cellular proliferations surrounding fibrovascular cores, with or without invasion [1]. Under a microscope, IPC looks similar to fingerlike projections called papules, which are characteristic of intraductal papillary carcinoma [15].

Incidence and Demographics

IPC is more likely to occur in postmenopausal women and is relatively rare in men, accounting for about 2-4% of all cases of invasive breast cancer in males [11][16]. The incidence of IPC is greater in older postmenopausal women.

Clinical Manifestations

The clinical manifestations of IPC are not well-defined, but it is often associated with a lump or swelling in the breast and changes to the nipple [9].

Diagnostic Criteria

IPC was defined as aggressive adenocarcinoma in the 2012 WHO classification system. It is characterized by the presence of papillary structures in more than 90% of its invasive components.

References:

[1] Abstract. [7] by C Liu · 2023 [11] Clinical manifestations. [12] Invasive papillary carcinoma (IPC) of the breast is a rare form of cancer. [15] Papillary carcinoma of the breast, also known as intraductal papillary carcinoma, is a rare type of breast cancer that accounts for only 0.5% of all new cases of invasive breast cancers.

Based on my analysis, I was unable to find any information about "obsolete intraductal papillary adenocarcinoma with invasion" in the provided search results. However, I can provide you with some general information about signs and symptoms of invasive ductal carcinoma (IDC), which is a type of breast cancer that may be related.

Common Signs and Symptoms:

• Swelling of all or part of the breast [1]
• Skin irritation [1]
• Skin dimpling, sometimes looking like an orange peel texture [1]
• Changes in breast size or appearance [2]
• Pain in the breast or chest area [2]
• A lump in the breast [5]

Other Possible Signs and Symptoms:

• Discharge from the nipple [5]
• Swelling of the breast [5]
• Thickening or puckering of the skin on and around the breast [7]
• Redness, dimpling, puckering, or unexplained rash on the skin [8]
• A lump, thickening, or swelling on the breast or underarm [9]

Please note that these symptoms can also be associated with other conditions, not just invasive ductal carcinoma. If you're concerned about your health, it's essential to consult a medical professional for an accurate diagnosis and advice.

References: [1] - Signs and symptoms of invasive ductal carcinoma [2] - Symptoms of breast cancer [5] - Invasive Ductal Carcinoma Symptoms [7] - Changes to look for may include a lump, an area of puckered or otherwise unusual skin, a thickened region under the skin, and nipple discharge. [8] - Symptoms · Changes to the skin on and around the breast, including redness, dimpling, puckering or unexplained rash · Fluid discharge from the ... [9] - What are the symptoms of papillary breast cancer?

Based on the available information, it appears that there are various treatment options for invasive intraductal papillary adenocarcinoma (IPMN) and intraductal papillary carcinoma (IPC).

• Adjuvant therapy may be beneficial in invasive IPMN, but current data suggest that it should be given selectively based on individual tumor characteristics [1].
• For invasive IPCs, adjuvant radiotherapy is recommended for all in-situ lesions and invasive papillary carcinomas, while systemic chemotherapy is reserved for lymph node-positive cases [8].
• Adjuvant therapy has been associated with improved overall survival (OS) compared to surgery alone in patients with invasive IPMN, particularly those with higher stage disease [9].

In terms of specific drug treatments, the available information does not provide a clear answer. However, it is mentioned that chemotherapy may be recommended for some people who have an invasive type of papillary breast cancer [10]. Additionally, targeted therapies are a group of drugs that block specific proteins involved in tumor growth and progression, but their use in treating IPMN or IPC is not specified.

It's worth noting that the treatment options for IPMN and IPC may vary depending on individual patient factors, such as tumor stage, size, and location. Therefore, it's essential to consult with a healthcare professional for personalized advice.

References: [1] Aronsson et al. (2019) [context 1] [8] Otsuka et al. (2013) [context 8] [9] McMillan et al. (2016) [context 9] [10] [context 10]