Discuss This Drug

Hydrocortisone

CHEBI:CHEBI_17650

Definition

A 17alpha-hydroxy-C21-steroid that is pregn-4-ene substituted by oxo groups at positions 3 and 20 and hydroxy groups at positions 11, 17 and 21. Cortisol is a corticosteroid hormone or glucocorticoid produced by zona fasciculata of the adrenal cortex, which is a part of the adrenal gland. It is usually referred to as the "stress hormone" as it is involved in response to stress and anxiety, controlled by corticotropin-releasing hormone (CRH). It increases blood pressure and blood sugar, and reduces immune responses.

Chemical Information

Molecular Formula
C21H30O5
Molecular Mass
362.45990
Charge
0
SMILES
[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]1(C)[C@@]2([H])CC[C@]1(O)C(=O)CO
InChI
InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
InChIKey
JYGXADMDTFJGBT-VWUMJDOOSA-N

Alternative Names

  • (11beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione
  • 11beta-hydrocortisone
  • 11beta,17,21-trihydroxypregn-4-ene-3,20-dione
  • 11beta,17alpha,21-trihydroxy-4-pregnene-3,20-dione
  • 11beta,17alpha,21-Trihydroxy-4-pregnene-3,20-dione
  • 17-hydroxycorticosterone
  • 4-pregnen-11beta,17alpha,21-triol-3,20-dione
  • cortisol
  • Cortisol
  • hidrocortisona
  • hydrocortisone
  • Hydrocortisone
  • hydrocortisonum
  • Kendall's compound F
  • Reichstein's substance M

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

oboInOwl#hasDbXref
Wikipedia:Hydrocortisone
DRON_00010000
5492
core#notation
CHEBI:17650

Additional References

Wikipedia:Hydrocortisone

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
oboInOwl#hasDbXref
Wikipedia:Hydrocortisone
DRON_00010000
5492
oboInOwl#hasAlternativeId
CHEBI:58221
oboInOwl#id
CHEBI:17650
generic_name
1% Hydrocortisone
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_77746
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
chebi#has_parent_hydride
http://purl.obolibrary.org/obo/CHEBI_8386
BFO_0000053
http://purl.obolibrary.org/obo/DRON_00000060
brand_name
Medi-First Hydrocortisone 1%
product_ndc
64958-0034
brand_name_base
Poli-A
package_ndc
72162-2284-2
labeler_name
Mericon Industries
marketing_start_date
20210720
spl_id
a66c2f94-61e1-46c7-a401-02b1caeed664
listing_expiration_date
20241231
active_ingredient_name
HYDROCORTISONE SODIUM PHOSPHATE
nui
N0000175450
active_ingredient_strength
1.12 g/100g
upc
0307130560603
application_number
ANDA211764
marketing_category
BULK INGREDIENT
dosage_form
POULTICE
product_type
BULK INGREDIENT
route
RECTAL
package_marketing_start_date
28-AUG-96
spl_set_id
e60473f7-fd00-a477-e053-2a95a90ad4dd
owl#annotatedSource
t137790
owl#someValuesFrom
t3969727
rxcui
1494035
manufacturer_name
OL PHARMA TECH, LLC Drs PHARMACY
package_description
29 g in 1 TUBE (63629-8817-1)
has_treatment
http://purl.obolibrary.org/obo/DOID_9749
unii
05RMF7YPWN
brand_name_suffix
Anti-Itch Maximum Strength
core#notation
CHEBI:17650
pharm_class_moa
Corticosteroid Hormone Receptor Agonists [MoA]
pharm_class
Corticosteroid [EPC]
pharm_class_epc
Corticosteroid [EPC]
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class