Discuss This Drug

adefovir

CHEBI:CHEBI_2469

Definition

A member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens has been replaced by a 2-(6-amino-9H-purin-9-yl)ethoxy group. An inhibitor of HIV-1 reverse transcriptase, the bis(t-butoxycarbonyloxymethyl) ester (dipivoxil ester) prodrug is used to treat chronic hepatitis B viral infection.

Chemical Information

Molecular Formula
C8H12N5O4P
Molecular Mass
273.186
Charge
0
SMILES
N1(C2=C(C(N)=NC=N2)N=C1)CCOCP(O)(=O)O
InChI
InChI=1S/C8H12N5O4P/c9-7-6-8(11-3-10-7)13(4-12-6)1-2-17-5-18(14,15)16/h3-4H,1-2,5H2,(H2,9,10,11)(H2,14,15,16)
InChIKey
SUPKOOSCJHTBAH-UHFFFAOYSA-N

Alternative Names

  • {[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}phosphonic acid
  • 9-(2-(Phosphonomethoxy)ethyl)adenine
  • 9-(2-Phosphonylmethoxyethyl)adenine
  • Adefovir
  • DRG-0156
  • GS 0393
  • GS 393
  • GS-0393
  • HSDB 8079
  • N-(2-Phosphonylmethoxyethyl)adenine
  • PMEA

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
16521
oboInOwl#hasDbXref
Wikipedia:Adefovir
core#notation
CHEBI:2469

Additional References

Wikipedia:Adefovir

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
16521
oboInOwl#hasDbXref
Wikipedia:Adefovir
oboInOwl#id
CHEBI:2469
core#notation
CHEBI:2469
oboInOwl#hasAlternativeId
CHEBI:40188
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_49103
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
chebi#has_functional_parent
http://purl.obolibrary.org/obo/CHEBI_16708
chebi#is_conjugate_acid_of
http://purl.obolibrary.org/obo/CHEBI_134512
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
has_treatment
http://purl.obolibrary.org/obo/DOID_5497
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect6150
chebi#is_conjugate_base_of
http://purl.obolibrary.org/obo/CHEBI_134512
owl#someValuesFrom
t1027011
owl#annotatedSource
t152251