Amlodipine

CHEBI:CHEBI_2668

Definition

A fully substituted dialkyl 1,4-dihydropyridine-3,5-dicarboxylate derivative, which is used for the treatment of hypertension, chronic stable angina and confirmed or suspected vasospastic angina.

Chemical Information

Molecular Formula: C20H25ClN2O5
Molecular Mass: 408.87600
Charge: 0
SMILES: CCOC(=O)C1=C(COCCN)NC(C)=C(C1c1ccccc1Cl)C(=O)OC
InChI: InChI=1S/C20H25ClN2O5/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21/h5-8,17,23H,4,9-11,22H2,1-3H3
InChIKey: HTIQEAQVCYTUBX-UHFFFAOYSA-N

Alternative Names

3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
3-Ethyl-5-methyl (+-)-2-(2-aminoethoxymethyl)-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate
amlodipine
Amlodipine Free Base
amlodipino
amlodipinum

Treatment Applications

obsolete diphtheritic membranous angina
DOID:12302

View Disease →
intermediate coronary syndrome
DOID:8805

View Disease →

Drug Classification

dihydropyridine
CHEBI:50075

View Class →
ethyl ester
CHEBI:23990

View Class →
methyl ester
CHEBI:25248

View Class →
monochlorobenzenes
CHEBI:83403

View Class →
primary amino compound
CHEBI:50994

View Class →
t154492
t154791
t154948
t155053

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

Always consult with a healthcare professional before starting, stopping, or modifying any medication.
Side effects may vary and this list may not be comprehensive.
Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000: 17767
oboInOwl#hasDbXref: Wikipedia:Amlodipine
core#notation: CHEBI:2668

Additional References

Wikipedia:Amlodipine

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

oboInOwl#hasOBONamespace: chebi_ontology
DRON_00010000: 17767
generic_name: Amlodipine Besylate (Process 1)
brand_name: Katerzia
oboInOwl#hasDbXref: Wikipedia:Amlodipine
oboInOwl#id: CHEBI:2668
RO_0000087: http://purl.obolibrary.org/obo/CHEBI_38215
oboInOwl#inSubset: http://purl.obolibrary.org/obo/chebi#3_STAR
BFO_0000053: http://purl.obolibrary.org/obo/DRON_00020325
package_ndc: 60687-496-01
product_ndc: 63187-326
labeler_name: Daiichi Sankyo Inc.
marketing_start_date: 19920731
application_number: ANDA207435
brand_name_base: Katerzia
product_type: BULK INGREDIENT
marketing_category: BULK INGREDIENT FOR HUMAN PRESCRIPTION COMPOUNDING
dosage_form: SUSPENSION
has_treatment: http://purl.obolibrary.org/obo/DOID_0070233
spl_id: 0e8788cc-8c04-6f26-e063-6294a90a9a81
package_description: 90 TABLET in 1 BOTTLE (71093-147-03)
package_marketing_start_date: 19-MAR-03
rdf-schema#range: https://w3id.org/def/predibionto#has_drug_113394
owl#annotatedSource: t155659
owl#someValuesFrom: t3866940
listing_expiration_date: 20241231
core#notation: CHEBI:2668
pharm_class_epc: Dihydropyridine Calcium Channel Blocker [EPC]
pharm_class: Dihydropyridines [CS]
pharm_class_pe: Increased Diuresis [PE]
pharm_class_cs: Dihydropyridines [CS]
pharm_class_moa: Calcium Channel Antagonists [MoA]
brand_name_suffix: 2.5 mg
upc: 0300696565303
22-rdf-syntax-ns#type: http://www.w3.org/2002/07/owl#Class
route: ORAL
manufacturer_name: Daiichi Sankyo Inc.
active_ingredient_name: AMLODIPINE BENZOATE
active_ingredient_strength: 35 kg/35kg
nui: N0000175566
spl_set_id: 655a8751-5c51-91f6-e053-2991aa0ad4bf
rxcui: 2184126
unii: XD75TQ8A2P