Discuss This Drug

Chlorambucil

CHEBI:CHEBI_28830

Definition

A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.

Chemical Information

Molecular Formula
C14H19Cl2NO2
Molecular Mass
304.21160
Charge
0
SMILES
OC(=O)CCCc1ccc(cc1)N(CCCl)CCCl
InChI
InChI=1S/C14H19Cl2NO2/c15-8-10-17(11-9-16)13-6-4-12(5-7-13)2-1-3-14(18)19/h4-7H,1-3,8-11H2,(H,18,19)
InChIKey
JCKYGMPEJWAADB-UHFFFAOYSA-N

Alternative Names

  • 4-(p-bis(beta-chloroethyl)aminophenyl)butyric acid
  • 4-[p-[bis(2-chloroethyl)amino]phenyl]butyric acid
  • 4-{4-[bis(2-chloroethyl)amino]phenyl}butanoic acid
  • Ambochlorin
  • Chlorambucil
  • CHLORAMBUCIL
  • chloraminophen
  • gamma-[p-di(2-chloroethyl)aminophenyl]butyric acid
  • Leukeran
  • N,N-di-2-chloroethyl-gamma-p-aminophenylbutyric acid
  • phenylbutyric acid nitrogen mustard

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
2346
oboInOwl#hasDbXref
Wikipedia:Chlorambucil
core#notation
CHEBI:28830

Additional References

Wikipedia:Chlorambucil

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
2346
oboInOwl#hasDbXref
Wikipedia:Chlorambucil
oboInOwl#hasAlternativeId
CHEBI:48770
oboInOwl#id
CHEBI:28830
core#notation
CHEBI:28830
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_88188
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http://purl.obolibrary.org/obo/chebi#3_STAR
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
has_treatment
http://purl.obolibrary.org/obo/DOID_12029
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect14723
owl#annotatedSource
t166357
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t875520