Discuss This Drug

Busulfan

CHEBI:CHEBI_28901

Definition

A methanesulfonate ester that is butane-1,4-diol in which the hydrogens of the hydroxy groups are replaced by methanesulfonyl groups. An alkylating antineoplastic agent, it is used for the treatment of chronic myeloid leukemia (although it has been largely replaced by newer drugs). It is also used as an insect sterilant.

Chemical Information

Molecular Formula
C6H14O6S2
Molecular Mass
246.30200
Charge
0
SMILES
CS(=O)(=O)OCCCCOS(C)(=O)=O
InChI
InChI=1S/C6H14O6S2/c1-13(7,8)11-5-3-4-6-12-14(2,9)10/h3-6H2,1-2H3
InChIKey
COVZYZSDYWQREU-UHFFFAOYSA-N

Alternative Names

  • 1,4-Bis(methanesulfonoxy)butane
  • 1,4-Butanediol dimethanesulfonate
  • 1,4-Dimesyloxybutane
  • 1,4-Dimethanesulfonoxybutane
  • Bisulfex
  • busulfan
  • Busulfan
  • busulfano
  • busulfanum
  • butane-1,4-diyl dimethanesulfonate
  • Leucosulfan
  • Mablin
  • Mielucin
  • Misulban
  • Mitostan
  • Myeloleukon
  • Myleran
  • Tetramethylene bis(methanesulfonate)

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
1828
oboInOwl#hasDbXref
Wikipedia:Busulfan
core#notation
CHEBI:28901

Additional References

Wikipedia:Busulfan

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
1828
oboInOwl#hasDbXref
Wikipedia:Busulfan
oboInOwl#hasAlternativeId
CHEBI:3225
oboInOwl#id
CHEBI:28901
core#notation
CHEBI:28901
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_22333
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
chebi#has_functional_parent
http://purl.obolibrary.org/obo/CHEBI_41189
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
has_treatment
http://purl.obolibrary.org/obo/DOID_2224
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect14799
owl#annotatedSource
t169849
owl#someValuesFrom
t773530