tolvaptan
CHEBI:CHEBI_32246
Definition
A benzazepine derivative incorporating a benzenedicarboxamide function whch is a selective vasopressin V2 receptor antagonist used to treat euvolemic and hypervolemic hyponatremia. It is also used in the treatment of rapidly progressing autosomal dominant polycystic kidney disease to slow the rate of cyst development and renal insufficiency. Tolvaptan is a racemate consisting of a 1:1 mixture of 5R and 5S stereomers.
Chemical Information
- Molecular Formula
- C26H25ClN2O3
- Molecular Mass
- 448.950
- Charge
- 0
- SMILES
- CC1=CC=CC=C1C(=O)NC1=CC(C)=C(C=C1)C(=O)N1CCCC(O)C2=CC(Cl)=CC=C12
- InChI
- InChI=1S/C26H25ClN2O3/c1-16-6-3-4-7-20(16)25(31)28-19-10-11-21(17(2)14-19)26(32)29-13-5-8-24(30)22-15-18(27)9-12-23(22)29/h3-4,6-7,9-12,14-15,24,30H,5,8,13H2,1-2H3,(H,28,31)
- InChIKey
- GYHCTFXIZSNGJT-UHFFFAOYSA-N
Alternative Names
- jinarc
- N-[4-(7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-1-benzazepine-1-carbonyl)-3-methylphenyl]-2-methylbenzamide
- OPC 41061
- OPC-41061
- samsca
- tolvaptan
- Tolvaptan
Treatment Applications
-
Meckel syndromeView Disease →
DOID:0050778
-
Perlman syndromeView Disease →
DOID:0060476
-
hypotonia-cystinuria syndromeView Disease →
DOID:0060858
-
nephrotic syndrome type 20View Disease →
DOID:0070357
-
polycystic kidney disease 4View Disease →
DOID:0080212
-
nephrotic syndrome type 15View Disease →
DOID:0080271
-
polycystic kidney disease 5View Disease →
DOID:0080273
-
nephrotic syndrome type 5View Disease →
DOID:0080380
-
nephrotic syndrome type 13View Disease →
DOID:0080381
-
nephrotic syndrome type 3View Disease →
DOID:0080382
-
nephrotic syndrome type 4View Disease →
DOID:0080383
-
nephrotic syndrome type 11View Disease →
DOID:0080385
-
nephrotic syndrome type 12View Disease →
DOID:0080387
-
nephrotic syndrome type 8View Disease →
DOID:0080389
-
Fanconi renotubular syndrome 5View Disease →
DOID:0080761
-
Caroli syndromeView Disease →
DOID:0081394
-
polycystic kidney disease 1View Disease →
DOID:0110858
-
ventriculomegaly - cystic kidney diseaseView Disease →
DOID:0111625
-
diffuse cystic renal dysplasiaView Disease →
DOID:0111682
-
nephrotic syndrome type 21View Disease →
DOID:0112267
-
Denys-Drash syndromeView Disease →
DOID:3764
Drug Classification
-
benzazepineView Class →
CHEBI:35676
-
benzenedicarboxamideView Class →
CHEBI:38800
-
t186734
-
t186901
Important Medical Information
⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.
- Always consult with a healthcare professional before starting, stopping, or modifying any medication.
- Side effects may vary and this list may not be comprehensive.
- Drug interactions may occur with other medications.
Additional Identifiers
- DRON_00010000
- 358257
- oboInOwl#hasDbXref
- Wikipedia:Tolvaptan
- core#notation
- CHEBI:32246
Additional References
🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.
Additional Attributes
- oboInOwl#hasOBONamespace
- chebi_ontology
- DRON_00010000
- 358257
- oboInOwl#hasDbXref
- Wikipedia:Tolvaptan
- oboInOwl#id
- CHEBI:32246
- core#notation
- CHEBI:32246
- oboInOwl#inSubset
- http://purl.obolibrary.org/obo/chebi#3_STAR
- RO_0000087
- http://purl.obolibrary.org/obo/CHEBI_59680
- 22-rdf-syntax-ns#type
- http://www.w3.org/2002/07/owl#Class
- has_treatment
- http://purl.obolibrary.org/obo/DOID_0060977
- rdf-schema#range
- https://w3id.org/def/predibionto#has_drug_111938
- rdf-schema#domain
- https://w3id.org/def/predibionto#has_side_effect19379
- owl#annotatedSource
- t187151
- owl#someValuesFrom
- t1009728