Discuss This Drug

Colistin

CHEBI:CHEBI_37943

Definition

A multi-component mixture comprising mostly of colistin A (R = Me) and B (R = H), with small amounts of colistin C and other polymyxins, produced by certain strains of Bacillus polymyxa var. colistinus. An antibiotic, it is used as its sulfate salt (for oral or topical use) or as the sodium salt of the N-methylsulfonic acid derivative (the injectable form) in the treatment of severe Gram-negative infections, partiularly those due to Pseudomonas aeruginosa.

Chemical Information

Molecular Formula
C52H97N16O13R
Molecular Mass
1154.428
Charge
0
SMILES
C(C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H]1C(N[C@H](C(N[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(=O)NCC1)[C@@H](C)O)=O)CCN)=O)CCN)=O)CC(C)C)=O)CC(C)C)=O)CCN)=O)=O)CCN)=O)[C@@H](C)O)=O)CCN)=O)CCC[C@@H](C*)C

Alternative Names

  • Colistin
  • colistina
  • colistine
  • colistinum
  • polymyxin E

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
2709
oboInOwl#hasDbXref
PMID:28321410
core#notation
CHEBI:37943

Additional References

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
2709
oboInOwl#hasDbXref
PMID:28321410
oboInOwl#hasAlternativeId
CHEBI:659853
oboInOwl#id
CHEBI:37943
core#notation
CHEBI:37943
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_50909
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
BFO_0000051
http://purl.obolibrary.org/obo/CHEBI_59673
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
has_treatment
http://purl.obolibrary.org/obo/DOID_5053
rdf-schema#range
https://w3id.org/def/predibionto#has_drug_101101
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect22942
chebi#has_functional_parent
http://purl.obolibrary.org/obo/CHEBI_59662
owl#annotatedSource
t211090
owl#someValuesFrom
t899320