Vorinostat

CHEBI:CHEBI_45716

Definition

A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).

Chemical Information

Molecular Formula: C14H20N2O3
Molecular Mass: 264.32020
Charge: 0
SMILES: ONC(=O)CCCCCCC(=O)Nc1ccccc1
InChI: InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)
InChIKey: WAEXFXRVDQXREF-UHFFFAOYSA-N

Alternative Names

N-hydroxy-N'-phenyloctanediamide
octanedioic acid hydroxyamide phenylamide
SAHA
SHH
Suberanilohydroxamic acid
suberoylanilide hydroxamic acid
vorinostat
vorinostatum
Zolinza

Treatment Applications

obsolete mature T-cell neoplasm
DOID:1038

View Disease →
obsolete cutaneous fibrohistiocytic neoplasm
DOID:1908

View Disease →
obsolete T-cell neoplasm
DOID:5601

View Disease →

Drug Classification

dicarboxylic acid diamide
CHEBI:35779

View Class →
hydroxamic acid
CHEBI:24650

View Class →
t220234
t220444
t220539
t220613
t221026
t221229

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

Always consult with a healthcare professional before starting, stopping, or modifying any medication.
Side effects may vary and this list may not be comprehensive.
Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000: 194337
oboInOwl#hasDbXref: Wikipedia:Vorinostat
core#notation: CHEBI:45716

Additional References

Wikipedia:Vorinostat

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

oboInOwl#hasOBONamespace: chebi_ontology
DRON_00010000: 194337
oboInOwl#hasDbXref: Wikipedia:Vorinostat
oboInOwl#id: CHEBI:45716
core#notation: CHEBI:45716
chebi#has_functional_parent: http://purl.obolibrary.org/obo/CHEBI_9300
RO_0000087: http://purl.obolibrary.org/obo/CHEBI_61115
oboInOwl#inSubset: http://purl.obolibrary.org/obo/chebi#3_STAR
22-rdf-syntax-ns#type: http://www.w3.org/2002/07/owl#Class
has_treatment: http://purl.obolibrary.org/obo/DOID_4788
rdf-schema#range: https://w3id.org/def/predibionto#has_drug_111688
owl#annotatedSource: t221521
owl#someValuesFrom: t979151