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Doxazosin

CHEBI:CHEBI_4708

Definition

A member of the class of quinazolines that is quinazoline substituted by an amino group at position 4, methoxy groups at positions 6 and 7 and a piperazin-1-yl group at position 2 which in turn is substituted by a 2,3-dihydro-1,4-benzodioxin-2-ylcarbonyl group at position 4. An antihypertensive agent, it is used in the treatment of high blood pressure.

Chemical Information

Molecular Formula
C23H25N5O5
Molecular Mass
451.47510
Charge
0
SMILES
COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2ccccc2O1
InChI
InChI=1S/C23H25N5O5/c1-30-18-11-14-15(12-19(18)31-2)25-23(26-21(14)24)28-9-7-27(8-10-28)22(29)20-13-32-16-5-3-4-6-17(16)33-20/h3-6,11-12,20H,7-10,13H2,1-2H3,(H2,24,25,26)
InChIKey
RUZYUOTYCVRMRZ-UHFFFAOYSA-N

Alternative Names

  • 1-(4-Amino-6,7-dimethoxy-2-chinazolinyl)-4-(2,3-dihydro-1,4-benzodioxixin-2-ylcarbonyl)piperazin
  • 1-(4-Amino-6,7-Dimethoxy-2-quinazolinyl)-4-(1,4-benzodioxan-2-ylcarbonyl)piperazin
  • 2-[4-(2,3-dihydro-1,4-benzodioxin-2-ylcarbonyl)piperazin-1-yl]-6,7-dimethoxyquinazolin-4-amine
  • doxazosin
  • Doxazosin
  • doxazosina
  • doxazosine
  • doxazosinum

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
49276
oboInOwl#hasDbXref
Wikipedia:Doxazosin
core#notation
CHEBI:4708

Additional References

Wikipedia:Doxazosin

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

package_marketing_start_date
17-JAN-18
package_description
50 BLISTER PACK in 1 BOX (50268-222-15) / 1 TABLET in 1 BLISTER PACK (50268-222-11)
product_type
BULK INGREDIENT
marketing_category
EXPORT ONLY
dosage_form
TABLET, MULTILAYER, EXTENDED RELEASE
labeler_name
Upsher-Smith laboratories, LLC
application_number
ANDA205210
product_ndc
59651-893
listing_expiration_date
20241231
marketing_start_date
20210531
spl_id
d53bcc2c-29da-459a-b82b-b34d3dee074f
route
ORAL
package_ndc
68382-785-77
rxcui
1242408
manufacturer_name
Upsher-Smith laboratories, LLC
unii
86P6PQK0MU
spl_set_id
9f3b80cc-cb90-40b5-84d2-24e1c6ffa2ed
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
49276
oboInOwl#hasDbXref
Wikipedia:Doxazosin
oboInOwl#id
CHEBI:4708
generic_name
DOXAZOSIN
brand_name
DOXAZOSIN
brand_name_base
DOXAZOSIN
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_35674
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
active_ingredient_strength
50 kg/50kg
pharm_class
alpha-Adrenergic Blocker [EPC]
active_ingredient_name
DOXAZOSIN MESYLATE
brand_name_suffix
XL
upc
0308321359112
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
has_treatment
http://purl.obolibrary.org/obo/DOID_6681
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect25185
owl#annotatedSource
t224689
owl#someValuesFrom
t2999726
core#notation
CHEBI:4708