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Cladribine

CHEBI:CHEBI_567361

Definition

2'-Deoxyadenosine in which the hydrogen at position 2 on the purine ring has been substituted by chlorine. It inhibits the synthesis and repair of DNA, particularly in lymphocytes and monocytes, and is used as an antimetabolite antineoplastic drug for the treatment of lymphoid malignancies including hairy-cell leukaemia and chronic lymphocytic leukaemia.

Chemical Information

Molecular Formula
C10H12ClN5O3
Molecular Mass
285.68700
Charge
0
SMILES
Nc1nc(Cl)nc2n(cnc12)[C@H]1C[C@H](O)[C@@H](CO)O1
InChI
InChI=1S/C10H12ClN5O3/c11-10-14-8(12)7-9(15-10)16(3-13-7)6-1-4(18)5(2-17)19-6/h3-6,17-18H,1-2H2,(H2,12,14,15)/t4-,5+,6+/m0/s1
InChIKey
PTOAARAWEBMLNO-KVQBGUIXSA-N

Alternative Names

  • (2R,3S,5R)-5-(6-amino-2-chloropurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol
  • 2-CdA
  • 2-chloro-2'-deoxy-beta-adenosine
  • 2-chloro-2'-deoxyadenosine
  • 2-chloro-6-amino-9-(2-deoxy-beta-D-erythro-pentofuranosyl)purine
  • 2-chloro-deoxyadenosine
  • 2-chlorodeoxyadenosine
  • 2ClAdo
  • cladribina
  • cladribine
  • Cladribine
  • cladribinum
  • CldAdo

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

oboInOwl#hasDbXref
Wikipedia:Cladribine
DRON_00010000
44157
core#notation
CHEBI:567361

Additional References

Wikipedia:Cladribine

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

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44157
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CHEBI:567361
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CHEBI:567361
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_35705
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