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clocortolone

CHEBI:CHEBI_59582

Definition

16alpha-Methylpregna-1,4-diene-3,20-dione bearing hydroxy substituents at the 11beta and 21 positions, fluorine at position 6 and chlorine at position 9. A medium potency corticosteroid, it is used as its 21-O-pivalate or caproate ester for the relief of inflammatory and pruritic (itching) skin disorders.

Chemical Information

Molecular Formula
C22H28ClFO4
Molecular Mass
410.90700
Charge
0
SMILES
[H][C@@]12C[C@@H](C)[C@H](C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1(Cl)[C@@]2([H])C[C@H](F)C2=CC(=O)C=C[C@]12C
InChI
InChI=1S/C22H28ClFO4/c1-11-6-13-14-8-16(24)15-7-12(26)4-5-21(15,3)22(14,23)18(28)9-20(13,2)19(11)17(27)10-25/h4-5,7,11,13-14,16,18-19,25,28H,6,8-10H2,1-3H3/t11-,13+,14+,16+,18+,19-,20+,21+,22+/m1/s1
InChIKey
YMTMADLUXIRMGX-RFPWEZLHSA-N

Alternative Names

  • 9-chloro-6alpha-fluoro-11beta,21-dihydroxy-16alpha-methyl-1,4-pregnadien-3,20-dione
  • 9-chloro-6alpha-fluoro-11beta,21-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione
  • 9-chloro-6alpha-fluoro-16alpha-methyl-1,4-pregnadiene-11beta,21-diol-3,20-dione
  • clocortolona
  • clocortolone
  • clocortolonum

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
21249
oboInOwl#hasDbXref
Wikipedia:Clocortolone
core#notation
CHEBI:59582

Additional References

Wikipedia:Clocortolone

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Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
21249
oboInOwl#hasDbXref
Wikipedia:Clocortolone
oboInOwl#id
CHEBI:59582
core#notation
CHEBI:59582
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_59683
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect29560
owl#annotatedSource
t252547
owl#someValuesFrom
t581241