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Ketorolac

CHEBI:CHEBI_6129

Definition

A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.

Chemical Information

Molecular Formula
C15H13NO3
Molecular Mass
255.269
Charge
0
SMILES
N12C(C(C(=O)O)CC1)=CC=C2C(=O)C3=CC=CC=C3
InChI
InChI=1S/C15H13NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13/h1-7,11H,8-9H2,(H,18,19)
InChIKey
OZWKMVRBQXNZKK-UHFFFAOYSA-N

Alternative Names

  • (+-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
  • (+-)-ketorolac
  • ketorolac
  • ketorolaco
  • ketorolacum
  • rac-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
  • rac-ketorolac

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

oboInOwl#hasDbXref
Wikipedia:Ketorolac
DRON_00010000
35827
core#notation
CHEBI:6129

Additional References

Wikipedia:Ketorolac

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Additional Attributes

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