Discuss This Drug

nelarabine

CHEBI:CHEBI_63612

Definition

A purine nucleoside in which O-methylguanine is attached to arabinofuranose via a beta-N(9)-glycosidic bond. Inhibits DNA synthesis and causes cell death; a prodrug of 9-beta-D-arabinofuranosylguanine (ara-G).

Chemical Information

Molecular Formula
C11H15N5O5
Molecular Mass
297.26730
Charge
0
SMILES
COc1nc(N)nc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1O
InChI
InChI=1S/C11H15N5O5/c1-20-9-5-8(14-11(12)15-9)16(3-13-5)10-7(19)6(18)4(2-17)21-10/h3-4,6-7,10,17-19H,2H2,1H3,(H2,12,14,15)/t4-,6-,7+,10-/m1/s1
InChIKey
IXOXBSCIXZEQEQ-UHTZMRCNSA-N

Alternative Names

  • 2-Amino-9-beta-D-arabinofuranosyl-6-methoxy-9H-purine
  • 9-(beta-D-arabinofuranosyl)-6-methoxy-9H-purin-2-amine
  • Arranon
  • nelzarabine
  • Nelzarabine

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
274771
oboInOwl#hasDbXref
Reaxys:13568768
core#notation
CHEBI:63612

Additional References

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Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
274771
oboInOwl#hasDbXref
Reaxys:13568768
oboInOwl#id
CHEBI:63612
core#notation
CHEBI:63612
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_50266
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
chebi#has_functional_parent
http://purl.obolibrary.org/obo/CHEBI_73141
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
has_treatment
http://purl.obolibrary.org/obo/DOID_5599
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect30570
owl#annotatedSource
t262955
owl#someValuesFrom
t2910435