Discuss This Drug

pemetrexed

CHEBI:CHEBI_63616

Definition

An N-acylglutamic acid in which the N-acyl group is specified as 4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl. Inhibits thymidylate synthase (TS), 421 dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT).

Chemical Information

Molecular Formula
C20H21N5O6
Molecular Mass
427.41060
Charge
0
SMILES
Nc1nc(=O)c2c(CCc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)c[nH]c2[nH]1
InChI
InChI=1S/C20H21N5O6/c21-20-24-16-15(18(29)25-20)12(9-22-16)6-3-10-1-4-11(5-2-10)17(28)23-13(19(30)31)7-8-14(26)27/h1-2,4-5,9,13H,3,6-8H2,(H,23,28)(H,26,27)(H,30,31)(H4,21,22,24,25,29)/t13-/m0/s1
InChIKey
WBXPDJSOTKVWSJ-ZDUSSCGKSA-N

Alternative Names

  • N-{4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamic acid
  • pemetrexed

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

oboInOwl#hasDbXref
Wikipedia:Pemetrexed
DRON_00010000
68446
core#notation
CHEBI:63616

Additional References

Wikipedia:Pemetrexed

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

package_marketing_start_date
26-MAR-14
manufacturer_name
Shilpa Medicare Limited
package_description
1 kg in 1 CANISTER (63660-0008-1)
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
dosage_form
SOLUTION, CONCENTRATE
application_number
NDA208419
product_ndc
70121-2462
package_ndc
42367-531-33
oboInOwl#hasOBONamespace
chebi_ontology
oboInOwl#hasDbXref
Wikipedia:Pemetrexed
DRON_00010000
68446
oboInOwl#id
CHEBI:63616
generic_name
Pemetrexed Disodium Amorphous
brand_name
Pemfexy
brand_name_base
Pemfexy
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_63721
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
chebi#is_conjugate_acid_of
http://purl.obolibrary.org/obo/CHEBI_63724
rxcui
1728079
active_ingredient_name
PEMETREXED MONOHYDRATE
active_ingredient_strength
100 mg/4.2mL
unii
236Y2F7D9J
spl_set_id
8b660f68-b770-4e0a-b2f9-25e663deecc3
upc
0343598386621
nui
N0000000111
core#notation
CHEBI:63616
pharm_class_epc
Folate Analog Metabolic Inhibitor [EPC]
pharm_class
Folic Acid Metabolism Inhibitors [MoA]
pharm_class_moa
Folic Acid Metabolism Inhibitors [MoA]
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
route
INTRAVENTRICULAR
spl_id
c75eae86-fead-40b1-861a-0af1f27b3263
listing_expiration_date
20241231
marketing_start_date
20070907
labeler_name
Shilpa Medicare Limited
has_treatment
http://purl.obolibrary.org/obo/DOID_6201
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect30603
chebi#is_conjugate_base_of
http://purl.obolibrary.org/obo/CHEBI_63724
owl#annotatedSource
t262953
owl#someValuesFrom
t3006550