topiramate
CHEBI:CHEBI_63631
Definition
A hexose derivative that is 2,3:4,5-di-O-isopropylidene-beta-D-fructopyranose in which the hydroxy group has been converted to the corresponding sulfamate ester. It blocks voltage-dependent sodium channels and is used as an antiepileptic and for the prevention of migraine.
Chemical Information
- Molecular Formula
- C12H21NO8S
- Molecular Mass
- 339.36200
- Charge
- 0
- SMILES
- CC1(C)O[C@@H]2CO[C@@]3(COS(N)(=O)=O)OC(C)(C)O[C@H]3[C@@H]2O1
- InChI
- InChI=1S/C12H21NO8S/c1-10(2)18-7-5-16-12(6-17-22(13,14)15)9(8(7)19-10)20-11(3,4)21-12/h7-9H,5-6H2,1-4H3,(H2,13,14,15)/t7-,8-,9+,12+/m1/s1
- InChIKey
- KJADKKWYZYXHBB-XBWDGYHZSA-N
Alternative Names
- 2,3:4,5-bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate
- 2,3:4,5-di-O-isopropylidene-beta-D-fructopyranose sulfamate
- McN-4853
- RWJ-17021
- tipiramate
- tipiramato
- Topamax
- topiramate
- Topiramate
- topiramato
- topiramatum
- TPM
Drug Classification
-
cyclic ketalView Class →
CHEBI:59779
-
sulfamate esterView Class →
CHEBI:48199
-
ketohexose derivativeView Class →
CHEBI:63391
-
t262243
-
t262383
-
t262927
Important Medical Information
⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.
- Always consult with a healthcare professional before starting, stopping, or modifying any medication.
- Side effects may vary and this list may not be comprehensive.
- Drug interactions may occur with other medications.
Additional Identifiers
- DRON_00010000
- 38404
- oboInOwl#hasDbXref
- Wikipedia:Topiramate
- core#notation
- CHEBI:63631
Additional References
🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.
Additional Attributes
- oboInOwl#hasOBONamespace
- chebi_ontology
- DRON_00010000
- 38404
- oboInOwl#hasDbXref
- Wikipedia:Topiramate
- oboInOwl#id
- CHEBI:63631
- oboInOwl#hasAlternativeId
- CHEBI:9633
- brand_name
- QUDEXY XR
- brand_name_base
- QUDEXY
- generic_name
- topiramate spinkle
- product_ndc
- 76420-276
- RO_0000087
- http://purl.obolibrary.org/obo/CHEBI_38633
- oboInOwl#inSubset
- http://purl.obolibrary.org/obo/chebi#3_STAR
- BFO_0000053
- http://purl.obolibrary.org/obo/DRON_00698710
- labeler_name
- Wuxi Haocheng Kerui Pharmaceutical Technology Co., Ltd.
- product_type
- BULK INGREDIENT
- marketing_category
- BULK INGREDIENT FOR HUMAN PRESCRIPTION COMPOUNDING
- dosage_form
- BEAD
- application_number
- ANDA217869
- package_ndc
- 65267-103-00
- route
- ORAL
- spl_id
- eb66045e-43b6-46c2-ac9d-c7ccc7f938b4
- listing_expiration_date
- 20241231
- marketing_start_date
- 20210305
- package_description
- 30 CAPSULE, EXTENDED RELEASE in 1 BOTTLE (70710-1043-3)
- package_marketing_start_date
- 13-MAR-23
- manufacturer_name
- Supernus Pharmaceuticals
- has_treatment
- http://purl.obolibrary.org/obo/DOID_0081424
- rdf-schema#domain
- https://w3id.org/def/predibionto#has_side_effect30749
- owl#annotatedSource
- t262784
- owl#someValuesFrom
- t3862133
- upc
- 0368071308839
- active_ingredient_strength
- 40 kg/40kg
- nui
- N0000182140
- active_ingredient_name
- TOPIRAMATE
- spl_set_id
- 57016639-89fe-43ad-89c4-5e7a756dddec
- rxcui
- 1494781
- unii
- 0H73WJJ391
- core#notation
- CHEBI:63631
- pharm_class_pe
- Decreased Central Nervous System Disorganized Electrical Activity [PE]
- pharm_class
- Cytochrome P450 2C19 Inhibitors [MoA]
- pharm_class_moa
- Cytochrome P450 2C19 Inhibitors [MoA]
- brand_name_suffix
- XR
- 22-rdf-syntax-ns#type
- http://www.w3.org/2002/07/owl#Class