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Topotecan

CHEBI:CHEBI_63632

Definition

A pyranoindolizinoquinoline used as an antineoplastic agent. It is a derivative of camptothecin and works by binding to the topoisomerase I-DNA complex and preventing religation of these 328 single strand breaks.

Chemical Information

Molecular Formula
C23H23N3O5
Molecular Mass
421.44580
Charge
0
SMILES
CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4ccc(O)c(CN(C)C)c4cc3Cn1c2=O
InChI
InChI=1S/C23H23N3O5/c1-4-23(30)16-8-18-20-12(9-26(18)21(28)15(16)11-31-22(23)29)7-13-14(10-25(2)3)19(27)6-5-17(13)24-20/h5-8,27,30H,4,9-11H2,1-3H3/t23-/m0/s1
InChIKey
UCFGDBYHRUNTLO-QHCPKHFHSA-N

Alternative Names

  • (4S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
  • 9-[(dimethylamino)methyl]-10-hydroxy-(4S)-camptothecin
  • topotecan
  • Topotecan
  • topotecane
  • topotecanum

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
57308
oboInOwl#hasDbXref
Wikipedia:Topotecan
core#notation
CHEBI:63632

Additional References

Wikipedia:Topotecan

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
57308
oboInOwl#hasDbXref
Wikipedia:Topotecan
oboInOwl#id
CHEBI:63632
core#notation
CHEBI:63632
oboInOwl#hasAlternativeId
CHEBI:9634
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_50276
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
has_treatment
http://purl.obolibrary.org/obo/DOID_5752
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect30762
owl#annotatedSource
t262935
owl#someValuesFrom
t3029157