Discuss This Drug

Vemurafenib

CHEBI:CHEBI_63637

Definition

A pyrrolopyridine that is 1H-pyrrolo[2,3-b]pyridine which is substituted at position 5 by a p-chlorophenyl group and at positions 3 by a 3-amino-2,6-difluorobenzoyl group, the amino group of which has undergone formal condensation with propane-1-sulfonic acid to give the corresponding sulfonamide. An inhibitor of BRAF and other kinases.

Chemical Information

Molecular Formula
C23H18ClF2N3O3S
Molecular Mass
489.920
Charge
0
SMILES
CCCS(=O)(=O)NC1=CC=C(F)C(C(=O)C2=CNC3=C2C=C(C=N3)C2=CC=C(Cl)C=C2)=C1F
InChI
InChI=1S/C23H18ClF2N3O3S/c1-2-9-33(31,32)29-19-8-7-18(25)20(21(19)26)22(30)17-12-28-23-16(17)10-14(11-27-23)13-3-5-15(24)6-4-13/h3-8,10-12,29H,2,9H2,1H3,(H,27,28)
InChIKey
GPXBXXGIAQBQNI-UHFFFAOYSA-N

Alternative Names

  • N-(3-{[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl}-2,4-difluorophenyl)propane-1-sulfonamide
  • PLX 4032
  • PLX-4032
  • PLX4032
  • RG 7204
  • RG-7204
  • RG7204
  • Ro 51-85426
  • RO 5185426
  • RO-51-85426
  • RO-5185426
  • RO5185426
  • vemurafenib
  • vemurafenibum
  • Zelboraf

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
1147220
oboInOwl#hasDbXref
Wikipedia:Vemurafenib
core#notation
CHEBI:63637

Additional References

Wikipedia:Vemurafenib

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
1147220
oboInOwl#hasDbXref
Wikipedia:Vemurafenib
oboInOwl#hasAlternativeId
CHEBI:194457
oboInOwl#id
CHEBI:63637
core#notation
CHEBI:63637
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_75047
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
has_treatment
http://purl.obolibrary.org/obo/DOID_5233
owl#annotatedSource
t262896
owl#someValuesFrom
t1092894