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leflunomide

CHEBI:CHEBI_6402

Definition

A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.

Chemical Information

Molecular Formula
C12H9F3N2O2
Molecular Mass
270.20730
Charge
0
SMILES
Cc1oncc1C(=O)Nc1ccc(cc1)C(F)(F)F
InChI
InChI=1S/C12H9F3N2O2/c1-7-10(6-16-19-7)11(18)17-9-4-2-8(3-5-9)12(13,14)15/h2-6H,1H3,(H,17,18)
InChIKey
VHOGYURTWQBHIL-UHFFFAOYSA-N

Alternative Names

  • 5-Methyl-N-(4-(trifluoromethyl)phenyl)-4-isoxazolecarboxamide
  • 5-Methylisoxazole-4-carboxylic acid (4-trifluoromethyl)anilide
  • alpha,alpha,alpha-Trifluoro-5-methyl-4-isoxazolecarboxy-p-toluidide
  • Arava
  • leflunomida
  • leflunomide
  • Leflunomide
  • leflunomidum
  • 5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:6402
DRON_00010000
27169
oboInOwl#hasDbXref
Wikipedia:Leflunomide

Additional References

Wikipedia:Leflunomide

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Additional Attributes

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chebi_ontology
oboInOwl#id
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core#notation
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22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
DRON_00010000
27169
oboInOwl#hasDbXref
Wikipedia:Leflunomide
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_68543
has_treatment
http://purl.obolibrary.org/obo/DOID_2980
Medication
http://purl.obolibrary.org/obo/DOID_0040086
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t266266
owl#someValuesFrom
t726019
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https://w3id.org/def/predibionto#has_side_effect30950