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Lomustine

CHEBI:CHEBI_6520

Definition

An N-nitrosourea that is urea in which one of the nitrogens is substituted by a 2-chloroethyl group and by a nitroso group, while the other nitrogen is substituted by a cyclohexyl group. An alkylating antineoplastic agent, it is used in the treatment of brain tumours, lung cancer, malignant melanoma and other solid tumours.

Chemical Information

Molecular Formula
C9H16ClN3O2
Molecular Mass
233.69500
Charge
0
SMILES
ClCCN(N=O)C(=O)NC1CCCCC1
InChI
InChI=1S/C9H16ClN3O2/c10-6-7-13(12-15)9(14)11-8-4-2-1-3-5-8/h8H,1-7H2,(H,11,14)
InChIKey
GQYIWUVLTXOXAJ-UHFFFAOYSA-N

Alternative Names

  • 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea
  • 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea
  • 1-(2-chloroethyl)-3-cyclohexylnitrosourea
  • Belustine
  • CCNU
  • Cecenu
  • CeeNU
  • chloroethylcyclohexylnitrosourea
  • CINU
  • cyclohexyl chloroethyl nitrosourea
  • lomustina
  • lomustine
  • lomustinum
  • N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosourea

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
6466
oboInOwl#hasDbXref
Wikipedia:Lomustine
core#notation
CHEBI:6520

Additional References

Wikipedia:Lomustine

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Additional Attributes

oboInOwl#hasOBONamespace
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DRON_00010000
6466
oboInOwl#hasDbXref
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oboInOwl#id
CHEBI:6520
core#notation
CHEBI:6520
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_22333
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22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
has_treatment
http://purl.obolibrary.org/obo/DOID_6128
owl#annotatedSource
t269203
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