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ivacaftor

CHEBI:CHEBI_66901

Definition

An aromatic amide obtained by formal condensation of the carboxy group of 4-oxo-1,4-dihydroquinoline-3-carboxylic acid with the amino group of 5-amino-2,4-di-tert-butylphenol. Used for the treatment of cystic fibrosis.

Chemical Information

Molecular Formula
C24H28N2O3
Molecular Mass
392.49070
Charge
0
SMILES
CC(C)(C)c1cc(c(NC(=O)c2c[nH]c3ccccc3c2=O)cc1O)C(C)(C)C
InChI
InChI=1S/C24H28N2O3/c1-23(2,3)16-11-17(24(4,5)6)20(27)12-19(16)26-22(29)15-13-25-18-10-8-7-9-14(18)21(15)28/h7-13,27H,1-6H3,(H,25,28)(H,26,29)
InChIKey
PURKAOJPTOLRMP-UHFFFAOYSA-N

Alternative Names

  • ivacaftor
  • ivacaftorum
  • Kalydeco
  • N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide
  • VX-770

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
1243041
oboInOwl#hasDbXref
Wikipedia:Ivacaftor
core#notation
CHEBI:66901

Additional References

Wikipedia:Ivacaftor

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
1243041
oboInOwl#hasDbXref
Wikipedia:Ivacaftor
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CHEBI:66901
core#notation
CHEBI:66901
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_71031
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http://purl.obolibrary.org/obo/chebi#3_STAR
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
has_treatment
http://purl.obolibrary.org/obo/DOID_0050739
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https://w3id.org/def/predibionto#has_side_effect31528
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t269675
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t3969831