Discuss This Drug

axitinib

CHEBI:CHEBI_66910

Definition

An indazole substituted at position 3 by a 2-(pyridin-2-yl)vinyl group and at position 6 by a 2-(N-methylaminocarboxy)phenylsulfanyl group. Used for the treatment of advanced renal cell carcinoma after failure of a first line systemic treatment.

Chemical Information

Molecular Formula
C22H18N4OS
Molecular Mass
386.47000
Charge
0
SMILES
CNC(=O)c1ccccc1Sc1ccc2c(\C=C\c3ccccn3)n[nH]c2c1
InChI
InChI=1S/C22H18N4OS/c1-23-22(27)18-7-2-3-8-21(18)28-16-10-11-17-19(25-26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-14H,1H3,(H,23,27)(H,25,26)/b12-9+
InChIKey
RITAVMQDGBJQJZ-FMIVXFBMSA-N

Alternative Names

  • AG-013736
  • axitinib
  • axitinibum
  • Inlyta
  • N-methyl-2-({3-[(E)-2-(pyridin-2-yl)ethenyl]-1H-indazol-6-yl}sulfanyl)benzamide
  • N-methyl-2-({3-[(E)-2-(pyridin-2-yl)vinyl]-1H-indazol-6-yl}sulfanyl)benzamide

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
1242999
oboInOwl#hasDbXref
Wikipedia:Axitinib
core#notation
CHEBI:66910

Additional References

Wikipedia:Axitinib

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
1242999
oboInOwl#hasDbXref
Wikipedia:Axitinib
oboInOwl#id
CHEBI:66910
core#notation
CHEBI:66910
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_65207
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
has_treatment
http://purl.obolibrary.org/obo/DOID_0081416
owl#annotatedSource
t268884
owl#someValuesFrom
t1101906
rdf-schema#range
https://w3id.org/def/predibionto#has_drug_113178
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect31550