Discuss This Drug

clofarabine

CHEBI:CHEBI_681569

Definition

A purine nucleoside analogue consisting of a 6-amino-2-chloropurin-9-yl group attached to the 1beta position of 2'-deoxy-2'-fluoro-D-arabinofuranose. It is metabolized intracellularly to the active 5'-triphosphate metabolite, which inhibits DNA synthesisis and so stops the growth of cancer cells. Clofarabine is used as an antimetabolite antineoplastic agent in the treatment of relapsed or refractory acute lymphoblastic leukaemia.

Chemical Information

Molecular Formula
C10H11ClFN5O3
Molecular Mass
303.67700
Charge
0
SMILES
Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1F
InChI
InChI=1S/C10H11ClFN5O3/c11-10-15-7(13)5-8(16-10)17(2-14-5)9-4(12)6(19)3(1-18)20-9/h2-4,6,9,18-19H,1H2,(H2,13,15,16)/t3-,4+,6-,9-/m1/s1
InChIKey
WDDPHFBMKLOVOX-AYQXTPAHSA-N

Alternative Names

  • (2R,3R,4S,5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol
  • 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purin-6-amine
  • 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)adenine
  • 2-chloro-9-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)adenine
  • CAFdA
  • Cl-F-Ara-A
  • clofarabina
  • clofarabine
  • clofarabine
  • clofarabinum

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
44151
oboInOwl#hasDbXref
Wikipedia:Clofarabine
core#notation
CHEBI:681569

Additional References

Wikipedia:Clofarabine

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

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chebi_ontology
DRON_00010000
44151
oboInOwl#hasDbXref
Wikipedia:Clofarabine
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CHEBI:681569
core#notation
CHEBI:681569
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_35610
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http://purl.obolibrary.org/obo/chebi#3_STAR
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
has_treatment
http://purl.obolibrary.org/obo/DOID_3405
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https://w3id.org/def/predibionto#has_side_effect32028
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t273139
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t3056251