Discuss This Drug

regorafenib

CHEBI:CHEBI_68647

Definition

A pyridinecarboxamide obtained by condensation of 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]pyridine-2-carboxylic acid with methylamine. Used for for the treatment of metastatic colorectal cancer in patients who have previously received chemotherapy, anti-EGFR or anti-VEGF therapy.

Chemical Information

Molecular Formula
C21H15ClF4N4O3
Molecular Mass
482.816
Charge
0
SMILES
C1(=C(C=C(C=C1)NC(NC2=CC=C(C=C2F)OC3=CC=NC(=C3)C(NC)=O)=O)C(F)(F)F)Cl
InChI
InChI=1S/C21H15ClF4N4O3/c1-27-19(31)18-10-13(6-7-28-18)33-12-3-5-17(16(23)9-12)30-20(32)29-11-2-4-15(22)14(8-11)21(24,25)26/h2-10H,1H3,(H,27,31)(H2,29,30,32)
InChIKey
FNHKPVJBJVTLMP-UHFFFAOYSA-N

Alternative Names

  • 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide
  • BAY 73-4506
  • regorafenib
  • regorafenibum
  • Regorafenibum

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
1312397
oboInOwl#hasDbXref
Wikipedia:Regorafenib
core#notation
CHEBI:68647

Additional References

Wikipedia:Regorafenib

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

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chebi_ontology
DRON_00010000
1312397
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Wikipedia:Regorafenib
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CHEBI:68647
core#notation
CHEBI:68647
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_50908
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http://purl.obolibrary.org/obo/DOID_6268
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t276591
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t1123969