Carglumic acid
CHEBI:CHEBI_71028
Definition
A urea that is the N-carbamoyl derivative of L-glutamic acid. An orphan drug used to treat a deficiency in the enzyme N-acetylglutamate synthase, which leads to acute hyperammonaemia.
Chemical Information
- Molecular Formula
- C6H10N2O5
- Molecular Mass
- 190.15400
- Charge
- 0
- SMILES
- NC(=O)N[C@@H](CCC(O)=O)C(O)=O
- InChI
- InChI=1S/C6H10N2O5/c7-6(13)8-3(5(11)12)1-2-4(9)10/h3H,1-2H2,(H,9,10)(H,11,12)(H3,7,8,13)/t3-/m0/s1
- InChIKey
- LCQLHJZYVOQKHU-VKHMYHEASA-N
Alternative Names
- (2S)-2-(carbamoylamino)pentanedioic acid
- acide carglumique
- acido carglumico
- acidum carglumicum
- Carbaglu
- Carbamino-L-glutamic acid
- Carbamylglutamic acid
- carglumic acid
- L-N-Carbamoylglutamic acid
- N-carbamoyl-L-glutamic acid
- Ureidoglutaric acid
Treatment Applications
-
2-hydroxyglutaric aciduriaView Disease →
DOID:0050573
-
L-2-hydroxyglutaric aciduriaView Disease →
DOID:0050574
-
ornithine translocase deficiencyView Disease →
DOID:0050720
-
adenylosuccinase lyase deficiencyView Disease →
DOID:0050762
-
3-methylglutaconic aciduriaView Disease →
DOID:0060336
-
lysinuric protein intoleranceView Disease →
DOID:0060439
-
dicarboxylic aminoaciduriaView Disease →
DOID:0060650
-
3-methylglutaconic aciduria type 8View Disease →
DOID:0070000
-
3-methylglutaconic aciduria type 9View Disease →
DOID:0070002
-
infantile liver failure syndromeView Disease →
DOID:0080716
-
infantile liver failure syndrome 1View Disease →
DOID:0080717
-
3-methylglutaconic aciduria type 7aView Disease →
DOID:0081133
-
3-methylglutaconic aciduria type 7bView Disease →
DOID:0081134
-
oxoglutarate dehydrogenase deficiencyView Disease →
DOID:0081326
-
3-methylglutaconic aciduria type 5View Disease →
DOID:0110000
-
3-methylglutaconic aciduria type 1View Disease →
DOID:0110002
-
3-methylglutaconic aciduria type 4View Disease →
DOID:0110006
-
Gaucher's disease perinatal lethalView Disease →
DOID:0110960
-
glutaric acidemia IView Disease →
DOID:0111254
-
glutaric acidemia type 3View Disease →
DOID:0112246
-
N-acetylglutamate synthase deficiencyView Disease →
DOID:0112258
-
Rett syndromeView Disease →
DOID:1206
-
urea cycle disorderView Disease →
DOID:9267
-
sialuriaView Disease →
DOID:3659
Drug Classification
-
ureasView Class →
CHEBI:47857
-
N-acyl-L-glutamic acidView Class →
CHEBI:21650
-
t279206
-
t279756
Important Medical Information
⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.
- Always consult with a healthcare professional before starting, stopping, or modifying any medication.
- Side effects may vary and this list may not be comprehensive.
- Drug interactions may occur with other medications.
Additional Identifiers
- DRON_00010000
- 401713
- oboInOwl#hasDbXref
- Wikipedia:Carglumic_acid
- core#notation
- CHEBI:71028
Additional References
🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.
Additional Attributes
- oboInOwl#hasOBONamespace
- chebi_ontology
- DRON_00010000
- 401713
- oboInOwl#hasDbXref
- Wikipedia:Carglumic_acid
- oboInOwl#id
- CHEBI:71028
- core#notation
- CHEBI:71028
- RO_0000087
- http://purl.obolibrary.org/obo/CHEBI_71033
- oboInOwl#inSubset
- http://purl.obolibrary.org/obo/chebi#3_STAR
- 22-rdf-syntax-ns#type
- http://www.w3.org/2002/07/owl#Class
- has_treatment
- http://purl.obolibrary.org/obo/DOID_0112258
- rdf-schema#range
- https://w3id.org/def/predibionto#has_drug_113625
- owl#annotatedSource
- t280219
- owl#someValuesFrom
- t3103886