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cabozantinib

CHEBI:CHEBI_72317

Definition

A dicarboxylic acid diamide that is N-phenyl-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide in which the hydrogen at position 4 on the phenyl ring is substituted by a (6,7-dimethoxyquinolin-4-yl)oxy group. A multi-tyrosine kinase inhibitor, used (as its malate salt) for the treatment of progressive, metastatic, medullary thyroid cancer.

Chemical Information

Molecular Formula
C28H24FN3O5
Molecular Mass
501.50570
Charge
0
SMILES
COc1cc2nccc(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3)c2cc1OC
InChI
InChI=1S/C28H24FN3O5/c1-35-24-15-21-22(16-25(24)36-2)30-14-11-23(21)37-20-9-7-19(8-10-20)32-27(34)28(12-13-28)26(33)31-18-5-3-17(29)4-6-18/h3-11,14-16H,12-13H2,1-2H3,(H,31,33)(H,32,34)
InChIKey
ONIQOQHATWINJY-UHFFFAOYSA-N

Alternative Names

  • BMS 907351
  • BMS-907351
  • N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
  • XL 184
  • XL-184
  • XL184

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
1363268
oboInOwl#hasDbXref
Wikipedia:Cabozantinib
core#notation
CHEBI:72317

Additional References

Wikipedia:Cabozantinib

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

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chebi_ontology
DRON_00010000
1363268
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CHEBI:72317
core#notation
CHEBI:72317
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_38637
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http://www.w3.org/2002/07/owl#Class
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http://purl.obolibrary.org/obo/DOID_0081416
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t280229
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t3000513