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temozolomide

CHEBI:CHEBI_72564

Definition

An imidazotetrazine that is 3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine which is substituted at positions 3, 4, and 8 by methyl, oxo, and carboxamide groups, respectively. A prodrug for MTIC (5-(3-methyltriaz-1-en-1-yl)-1H-imidazole-4-carboxamide, formed by spontaneous hydrolysis of temozolomide in the body), it is used as an oral alkylating agent for the treatment of newly diagnosed malignant glioblastoma multiforme (concomitantly with radiotherapy) and malignant melanoma.

Chemical Information

Molecular Formula
C6H6N6O2
Molecular Mass
194.15080
Charge
0
SMILES
Cn1nnc2c(ncn2c1=O)C(N)=O
InChI
InChI=1S/C6H6N6O2/c1-11-6(14)12-2-8-3(4(7)13)5(12)9-10-11/h2H,1H3,(H2,7,13)
InChIKey
BPEGJWRSRHCHSN-UHFFFAOYSA-N

Alternative Names

  • 3-methyl-4-oxo-3,4-dihydroimidazo(5,1-d)(1,2,3,5)tetrazine-8-carboxamide
  • 3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide
  • 3,4-dihydro-3-methyl-4-oxoimidazo(5,1-d)-1,2,3,5-tetrazine-8-carboxamide
  • 3,4-dihydro-3-methyl-4-oxoimidazo(5,1-d)-as-tetrazine-8-carboxamide
  • 8-carbamoyl-3-methylimidazo(5,1-d)-1,2,3,5-tetrazin-4(3H)-one
  • BRN 5547136
  • CCRG 81045
  • CCRG-81045
  • CCRIS 8996
  • M & B 39831
  • M&B 39831
  • MB 39831
  • methazolastone
  • NSC 362856
  • Sch 52365
  • Temodal
  • Temodar
  • temozolomida
  • temozolomide
  • temozolomidum
  • TMZ

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
37776
oboInOwl#hasDbXref
Wikipedia:Temozolomide
core#notation
CHEBI:72564

Additional References

Wikipedia:Temozolomide

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
37776
oboInOwl#hasDbXref
Wikipedia:Temozolomide
oboInOwl#id
CHEBI:72564
core#notation
CHEBI:72564
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_22333
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
has_treatment
http://purl.obolibrary.org/obo/DOID_5370
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect33567
owl#annotatedSource
t280207
owl#someValuesFrom
t980752