Discuss This Drug

Naltrexone

CHEBI:CHEBI_7465

Definition

An organic heteropentacyclic compound that is naloxone substituted in which the allyl group attached to the nitrogen is replaced by a cyclopropylmethyl group. A mu-opioid receptor antagonist, it is used to treat alcohol dependence.

Chemical Information

Molecular Formula
C20H23NO4
Molecular Mass
341.40096
Charge
0
SMILES
Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O)CC1CC1
InChI
InChI=1S/C20H23NO4/c22-13-4-3-12-9-15-20(24)6-5-14(23)18-19(20,16(12)17(13)25-18)7-8-21(15)10-11-1-2-11/h3-4,11,15,18,22,24H,1-2,5-10H2/t15-,18+,19+,20-/m1/s1
InChIKey
DQCKKXVULJGBQN-XFWGSAIBSA-N

Alternative Names

  • 17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-one
  • 17-(Cyclopropylmethyl)-4,5alpha-epoxy-3,14-dihydroxymorphinan-6-one
  • 3,14-dihydroxy-17-(cyclopropylmethyl)-4,5alpha-epoxymorphinan-6-one
  • N-Cyclopropylmethyl-14-hydroxydihydromorphinone
  • N-Cyclopropylmethylnoroxymorphone
  • naltrexone
  • Naltrexone

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
7243
oboInOwl#hasDbXref
Wikipedia:Naltrexone
core#notation
CHEBI:7465

Additional References

Wikipedia:Naltrexone

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

has_treatment
http://purl.obolibrary.org/obo/DOID_13781
listing_expiration_date
20241231
marketing_start_date
19900130
spl_id
0b776726-c9f4-a072-e063-6294a90ac0e0
labeler_name
FRANCOPIA
BFO_0000053
http://purl.obolibrary.org/obo/DRON_00000036
route
ORAL
package_ndc
58159-109-04
package_description
1000 g in 1 CONTAINER (51552-1588-3)
dosage_form
TABLET, FILM COATED, EXTENDED RELEASE
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT FOR HUMAN PRESCRIPTION COMPOUNDING
application_number
ANDA207905
product_ndc
51224-206
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
7243
oboInOwl#hasDbXref
Wikipedia:Naltrexone
oboInOwl#id
CHEBI:7465
generic_name
Naltrexone Methobromide
brand_name
VIVITROL
brand_name_base
VIVITROL
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_90755
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
chebi#is_conjugate_base_of
http://purl.obolibrary.org/obo/CHEBI_134688
package_marketing_start_date
10-SEP-14
rxcui
1551474
manufacturer_name
Nalpropion Pharmaceuticals LLC
unii
Z6375YW9SF
spl_set_id
00c04ff4-b6f2-466c-9ab9-813a60577db0
core#notation
CHEBI:7465
active_ingredient_strength
1000 g/1000g
pharm_class
Opioid Antagonists [MoA]
active_ingredient_name
METHYLNALTREXONE BROMIDE
brand_name_suffix
Extended-Release
upc
0368094853620
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect6193
chebi#is_conjugate_acid_of
http://purl.obolibrary.org/obo/CHEBI_134688
owl#someValuesFrom
t3047044
owl#annotatedSource
t283710