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(R)-ketorolac

CHEBI:CHEBI_76227

Definition

A 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid that has R configuration. Unlike the S-enantiomer, it does not exhibit COX1 and COX2 inhibition, but does exhibit analgesic activity. Racemic ketorolac, known simply as ketorolac, is used (mainly as a tromethamine salt) as a potent analgesic for the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis.

Chemical Information

Molecular Formula
C15H13NO3
Molecular Mass
255.26860
Charge
0
SMILES
OC(=O)[C@@H]1CCn2c1ccc2C(=O)c1ccccc1
InChI
InChI=1S/C15H13NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13/h1-7,11H,8-9H2,(H,18,19)/t11-/m1/s1
InChIKey
OZWKMVRBQXNZKK-LLVKDONJSA-N

Alternative Names

  • (+)-ketorolac
  • (1R)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
  • (R)-(+)-ketorolac

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

oboInOwl#hasDbXref
Reaxys:6064295
core#notation
CHEBI:76227

Additional References

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Additional Attributes

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http://purl.obolibrary.org/obo/chebi#3_STAR
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_35480
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http://purl.obolibrary.org/obo/CHEBI_76228
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t290324