tafamidis
CHEBI:CHEBI_78538
Definition
A member of the class of 1,3-benzoxazoles that is 1,3-benzoxazole-6-carboxylic acid in which the hydrogen at position 2 is replaced by a 3,5-dichlorophenyl group. Used (as its meglumine salt) for the amelioration of transthyretin-related hereditary amyloidosis.
Chemical Information
- Molecular Formula
- C14H7Cl2NO3
- Molecular Mass
- 308.11600
- Charge
- 0
- SMILES
- OC(=O)c1ccc2nc(oc2c1)-c1cc(Cl)cc(Cl)c1
- InChI
- InChI=1S/C14H7Cl2NO3/c15-9-3-8(4-10(16)6-9)13-17-11-2-1-7(14(18)19)5-12(11)20-13/h1-6H,(H,18,19)
- InChIKey
- TXEIIPDJKFWEEC-UHFFFAOYSA-N
Alternative Names
- 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid
- 2-(3,5-dichlorophenyl)benzoxazole-6-carboxylic acid
- Fx-1006
- tafamidis
- tafamidisum
Treatment Applications
-
infantile Refsum diseaseView Disease →
DOID:0050444
-
Charcot-Marie-Tooth disease type 4View Disease →
DOID:0050541
-
Charcot-Marie-Tooth disease type XView Disease →
DOID:0050542
-
Fukuyama congenital muscular dystrophyView Disease →
DOID:0050559
-
familial visceral amyloidosisView Disease →
DOID:0050636
-
Finnish type amyloidosisView Disease →
DOID:0050637
-
transthyretin amyloidosisView Disease →
DOID:0050638
-
Bietti crystalline corneoretinal dystrophyView Disease →
DOID:0050664
-
ataxia with oculomotor apraxia type 1View Disease →
DOID:0050754
-
obsolete paramyloidosisView Disease →
DOID:0050761
-
choreaacanthocytosisView Disease →
DOID:0050766
-
autosomal recessive cerebellar ataxiaView Disease →
DOID:0050950
-
pontocerebellar hypoplasia type 2AView Disease →
DOID:0060267
-
Hermansky-Pudlak syndrome 9View Disease →
DOID:0060547
-
hyperekplexia 2View Disease →
DOID:0060697
-
Pierson syndromeView Disease →
DOID:0060852
-
late-onset retinal degenerationView Disease →
DOID:0060869
-
CST3-related cerebral amyloid angiopathyView Disease →
DOID:0070027
-
APP-related cerebral amyloid angiopathyView Disease →
DOID:0070028
-
hypomyelinating leukodystrophy 23View Disease →
DOID:0070397
-
myofibrillar myopathy 1View Disease →
DOID:0080092
-
microcephaly and chorioretinopathy 3View Disease →
DOID:0080107
-
Joubert syndrome 31View Disease →
DOID:0080277
-
tuberous sclerosis 1View Disease →
DOID:0080324
-
tuberous sclerosis 2View Disease →
DOID:0080325
-
nephrotic syndrome type 6View Disease →
DOID:0080384
-
nephrotic syndrome type 9View Disease →
DOID:0080391
-
familial adenomatous polyposis 2View Disease →
DOID:0080410
-
Meier-Gorlin syndrome 4View Disease →
DOID:0080515
-
Meier-Gorlin syndrome 6View Disease →
DOID:0080517
-
Meier-Gorlin syndrome 7View Disease →
DOID:0080518
-
Klippel-Feil syndrome 2View Disease →
DOID:0080590
-
anterior segment dysgenesis 3View Disease →
DOID:0080608
-
oculocutaneous albinism type VIView Disease →
DOID:0080614
-
tubular aggregate myopathy 2View Disease →
DOID:0080686
-
autosomal dominant beta thalassemiaView Disease →
DOID:0080770
-
dialysis-related amyloidosisView Disease →
DOID:0080928
-
variant ABeta2M amyloidosisView Disease →
DOID:0080929
-
primary localized cutaneous amyloidosis 1View Disease →
DOID:0080930
-
primary localized cutaneous amyloidosis 2View Disease →
DOID:0080931
-
primary localized cutaneous amyloidosis 3View Disease →
DOID:0080932
-
immunoglobulin light chain amyloidosisView Disease →
DOID:0080933
-
immunoglobulin heavy chain amyloidosisView Disease →
DOID:0080934
-
immunoglobulin heavy-and-light chainView Disease →
DOID:0080935
-
serum amyloid A amyloidosisView Disease →
DOID:0080936
-
wild-type amyloidosisView Disease →
DOID:0080937
-
amelogenesis imperfecta type 1JView Disease →
DOID:0080953
-
amelogenesis imperfecta type 2A6View Disease →
DOID:0080960
-
Baraitser-Winter syndrome 1View Disease →
DOID:0081112
-
congenital myopathy 18View Disease →
DOID:0081350
-
autosomal dominant Alport syndromeView Disease →
DOID:0110032
-
autosomal recessive Alport syndromeView Disease →
DOID:0110033
-
lattice corneal dystrophyView Disease →
DOID:8943
-
amelogenesis imperfecta type 1EView Disease →
DOID:0110058
-
Charcot-Marie-Tooth disease axonal type 2OView Disease →
DOID:0110175
-
Wolfram syndrome 2View Disease →
DOID:0110630
-
congenital stationary night blindness 2AView Disease →
DOID:0110871
-
Joubert syndrome 10View Disease →
DOID:0110981
-
nephronophthisis 11View Disease →
DOID:0111118
-
nephronophthisis 12View Disease →
DOID:0111119
-
nephronophthisis 9View Disease →
DOID:0111120
-
nephronophthisis 13View Disease →
DOID:0111121
-
nephronophthisis 14View Disease →
DOID:0111122
-
nephronophthisis 16View Disease →
DOID:0111124
-
nephronophthisis 18View Disease →
DOID:0111125
-
nephronophthisis 19View Disease →
DOID:0111126
-
nephronophthisis 20View Disease →
DOID:0111127
-
focal segmental glomerulosclerosis 1View Disease →
DOID:0111128
-
focal segmental glomerulosclerosis 2View Disease →
DOID:0111129
-
focal segmental glomerulosclerosis 6View Disease →
DOID:0111131
-
focal segmental glomerulosclerosis 7View Disease →
DOID:0111132
-
focal segmental glomerulosclerosis 8View Disease →
DOID:0111133
-
focal segmental glomerulosclerosis 9View Disease →
DOID:0111134
-
Jalili syndromeView Disease →
DOID:0111404
-
X-linked exudative vitreoretinopathy 2View Disease →
DOID:0111413
-
dehydrated hereditary stomatocytosis 2View Disease →
DOID:0111577
-
CHILD syndromeView Disease →
DOID:0111822
-
X-linked congenital hemolytic anemiaView Disease →
DOID:0111846
-
oculocerebrorenal syndromeView Disease →
DOID:1056
-
POEMS syndromeView Disease →
DOID:14039
-
Clouston syndromeView Disease →
DOID:14693
-
amyloid tumorView Disease →
DOID:6755
Drug Classification
-
dichlorobenzeneView Class →
CHEBI:23697
-
DichlorobenzeneView Class →
CHEBI:23697
-
monocarboxylic acidView Class →
CHEBI:25384
-
1,3-benzoxazolesView Class →
CHEBI:51548
-
t296052
-
t296712
Important Medical Information
⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.
- Always consult with a healthcare professional before starting, stopping, or modifying any medication.
- Side effects may vary and this list may not be comprehensive.
- Drug interactions may occur with other medications.
Additional Identifiers
- DRON_00010000
- 1545063
- oboInOwl#hasDbXref
- Wikipedia:Tafamidis
- core#notation
- CHEBI:78538
Additional References
🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.
Additional Attributes
- oboInOwl#hasOBONamespace
- chebi_ontology
- DRON_00010000
- 1545063
- oboInOwl#hasDbXref
- Wikipedia:Tafamidis
- oboInOwl#id
- CHEBI:78538
- core#notation
- CHEBI:78538
- RO_0000087
- http://purl.obolibrary.org/obo/CHEBI_35470
- oboInOwl#inSubset
- http://purl.obolibrary.org/obo/chebi#3_STAR
- chebi#is_conjugate_acid_of
- http://purl.obolibrary.org/obo/CHEBI_79344
- 22-rdf-syntax-ns#type
- http://www.w3.org/2002/07/owl#Class
- rdf-schema#range
- https://w3id.org/def/predibionto#has_drug_112335
- rdf-schema#domain
- https://w3id.org/def/predibionto#has_side_effect35066
- has_treatment
- http://purl.obolibrary.org/obo/DOID_11775
- chebi#is_conjugate_base_of
- http://purl.obolibrary.org/obo/CHEBI_79344
- owl#annotatedSource
- t300599
- owl#someValuesFrom
- t2911438