apremilast
CHEBI:CHEBI_78540
Definition
A member of the class of isoindoles that is isoindole-1,3-dione substituted at position 4 by an acetamido group and at position 1 by a 1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl group. Used for treatment of psoriatic arthritis.
Chemical Information
- Molecular Formula
- C22H24N2O7S
- Molecular Mass
- 460.50000
- Charge
- 0
- SMILES
- CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)N1C(=O)c2cccc(NC(C)=O)c2C1=O
- InChI
- InChI=1S/C22H24N2O7S/c1-5-31-19-11-14(9-10-18(19)30-3)17(12-32(4,28)29)24-21(26)15-7-6-8-16(23-13(2)25)20(15)22(24)27/h6-11,17H,5,12H2,1-4H3,(H,23,25)/t17-/m1/s1
- InChIKey
- IMOZEMNVLZVGJZ-QGZVFWFLSA-N
Alternative Names
- apremilast
- apremilastum
- CC 10004
- CC-10004
- CC10004
- N-{2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide
- OTEZLA
Drug Classification
-
N-acetylarylamineView Class →
CHEBI:13790
-
phthalimidesView Class →
CHEBI:82851
-
t299729
-
t300699
-
sulfoneView Class →
CHEBI:35850
-
aromatic etherView Class →
CHEBI:35618
Important Medical Information
⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.
- Always consult with a healthcare professional before starting, stopping, or modifying any medication.
- Side effects may vary and this list may not be comprehensive.
- Drug interactions may occur with other medications.
Additional Identifiers
- core#notation
- CHEBI:78540
- oboInOwl#hasDbXref
- Wikipedia:Apremilast
- DRON_00010000
- 1492727
Additional References
🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.
Additional Attributes
- core#notation
- CHEBI:78540
- rxcui
- 2682432
- package_marketing_start_date
- 29-AUG-16
- active_ingredient_strength
- 12 kg/12kg
- upc
- 0355513137607
- nui
- N0000182960
- pharm_class_epc
- Phosphodiesterase 4 Inhibitor [EPC]
- pharm_class
- Phosphodiesterase 4 Inhibitors [MoA]
- pharm_class_moa
- Phosphodiesterase 4 Inhibitors [MoA]
- active_ingredient_name
- APREMILAST, (+/-)-
- package_description
- 1 BAG in 1 DRUM (53747-077-00) / 50 kg in 1 BAG
- manufacturer_name
- Amgen Inc
- unii
- UP7QBP99PN
- spl_set_id
- f6b1f516-4972-4d82-bced-113e47b41cc5
- 22-rdf-syntax-ns#type
- http://www.w3.org/2002/07/owl#Class
- oboInOwl#hasOBONamespace
- chebi_ontology
- oboInOwl#hasDbXref
- Wikipedia:Apremilast
- DRON_00010000
- 1492727
- generic_name
- Apremilast Form-M
- oboInOwl#id
- CHEBI:78540
- dosage_form
- POWDER
- product_type
- BULK INGREDIENT
- marketing_category
- BULK INGREDIENT FOR HUMAN PRESCRIPTION COMPOUNDING
- labeler_name
- Amgen Inc
- product_ndc
- 69766-024
- brand_name
- Otezla
- brand_name_base
- Otezla
- application_number
- NDA205437
- oboInOwl#inSubset
- http://purl.obolibrary.org/obo/chebi#3_STAR
- RO_0000087
- http://purl.obolibrary.org/obo/CHEBI_68844
- listing_expiration_date
- 20241231
- route
- ORAL
- marketing_start_date
- 20140325
- spl_id
- 0c36c28f-06e7-02a6-e063-6394a90a5b8b
- package_ndc
- 69766-024-04
- has_treatment
- http://purl.obolibrary.org/obo/DOID_0070526
- rdf-schema#domain
- https://w3id.org/def/predibionto#has_side_effect35090
- owl#annotatedSource
- t300685
- owl#someValuesFrom
- t2992428