ICD-10: C88.4

ICD-10 code C88.4 refers to Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue, commonly known as MALT lymphoma. Here are the clinical descriptions and details associated with this diagnosis:

• Classification: MALT lymphoma is classified as a type of non-Hodgkin lymphoma, specifically an extranodal marginal zone B-cell lymphoma. It arises from the abnormal proliferation of B lymphocytes in the mucosa-associated lymphoid tissue (MALT) found in various organs, including the stomach, lungs, thyroid gland, salivary glands, and ocular adnexa [3][10].

• Characteristics: This lymphoma is typically low-grade and is characterized by a heterogeneous population of centrocyte-like cells. It often presents with localized disease, which can involve the stomach (most commonly), but may also affect other mucosal sites [9][10].

• Symptoms: Patients may experience symptoms related to the affected organ, such as abdominal pain, gastrointestinal bleeding, or respiratory issues, depending on where the lymphoma is located. However, many patients may be asymptomatic at diagnosis [7].

• Diagnosis: The diagnosis is confirmed through histopathological examination and immunophenotyping, which helps differentiate MALT lymphoma from other types of lymphomas. Imaging studies may also be utilized to assess the extent of the disease [10].

• Prognosis and Treatment: MALT lymphoma generally has a favorable prognosis, especially when diagnosed early. Treatment options may include watchful waiting, radiation therapy, and in some cases, chemotherapy, particularly if the disease is more advanced or symptomatic [9][10].

• ICD-10 Specifics: The code C88.4 is a non-specific and non-billable diagnosis code, which means it may not be valid for certain billing purposes. It is advisable to use a more specific code when available for accurate medical documentation and billing [15].

This information provides a comprehensive overview of MALT lymphoma as classified under ICD-10 code C88.4, highlighting its clinical significance, characteristics, and management.

The diagnosis of Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT-lymphoma), classified under ICD-10 code C88.4, involves several criteria that are typically assessed by healthcare professionals. Here are the key diagnostic criteria:

• Histological Examination: The diagnosis is primarily based on histological analysis of tissue samples. The presence of a heterogeneous population of centrocyte-like cells, monocytoid cells, and scattered immunoblasts is indicative of MALT-lymphoma [4].

• Location of Lymphoma: MALT-lymphoma is characterized by its extranodal nature, meaning it arises in mucosa-associated lymphoid tissues. Common sites include the stomach, lung, thyroid gland, salivary gland, and ocular adnexa [12].

• Immunophenotyping: Immunophenotyping is used to identify the specific types of B lymphocytes involved. This helps differentiate MALT-lymphoma from other types of lymphomas and confirms the diagnosis [12].

• Clinical Presentation: Patients may present with symptoms related to the affected organ, such as abdominal pain or respiratory issues, depending on the lymphoma's location. The clinical history and physical examination findings are also important [12].

• Imaging Studies: Imaging techniques, such as CT scans or PET scans, may be employed to assess the extent of the disease and to identify any associated lymphadenopathy or organ involvement [12].

• Exclusion of Other Conditions: It is crucial to rule out other types of lymphomas and conditions that may mimic MALT-lymphoma, ensuring an accurate diagnosis [12].

These criteria collectively aid in establishing a definitive diagnosis of MALT-lymphoma, guiding appropriate treatment and management strategies.