ICD-10: E11.43

Type 2 diabetes mellitus with diabetic autonomic (poly)neuropathy

Clinical Information

Inclusion Terms

  • Type 2 diabetes mellitus with diabetic gastroparesis

Additional Information

Approximate Synonyms

ICD-10 code E11.43 refers specifically to Type 2 diabetes mellitus with diabetic autonomic (poly)neuropathy. This code is part of the broader classification of diabetes mellitus and is used for medical billing and documentation purposes. Below are alternative names and related terms associated with this condition.

Alternative Names

  1. Type 2 Diabetes with Autonomic Neuropathy: This is a more straightforward term that describes the same condition without the technical jargon of ICD coding.

  2. Diabetic Autonomic Neuropathy (DAN): This term emphasizes the neuropathic aspect of the condition, focusing on the autonomic nervous system's involvement.

  3. Diabetic Polyneuropathy: While this term can refer to a broader category of nerve damage in diabetes, it is often used interchangeably with autonomic neuropathy when discussing complications of diabetes.

  4. Diabetes Mellitus with Autonomic Dysfunction: This term highlights the dysfunction of the autonomic nervous system as a result of diabetes.

  5. Type 2 Diabetes with Nerve Damage: A layman's term that conveys the essence of the condition without medical terminology.

  1. Diabetes Mellitus: The overarching term for diabetes, which includes both Type 1 and Type 2 diabetes.

  2. Neuropathy: A general term for nerve damage, which can occur in various forms, including peripheral and autonomic neuropathy.

  3. Autonomic Nervous System: The part of the nervous system that controls involuntary bodily functions, which can be affected in diabetic patients.

  4. Diabetic Complications: A broader category that includes various health issues arising from diabetes, such as neuropathy, retinopathy, and nephropathy.

  5. Peripheral Neuropathy: While primarily referring to damage to the peripheral nerves, it is often discussed in the context of diabetes and can overlap with autonomic neuropathy.

  6. Diabetes-Related Neuropathy: A term that encompasses all types of nerve damage associated with diabetes, including both peripheral and autonomic forms.

  7. Chronic Diabetic Neuropathy: This term may be used to describe long-term nerve damage resulting from poorly managed diabetes.

Understanding these alternative names and related terms can help in better communication regarding the condition, whether in clinical settings or patient education. It is essential for healthcare providers to use precise terminology to ensure accurate diagnosis, treatment, and billing practices.

Diagnostic Criteria

The ICD-10 code E11.43 refers to Type 2 diabetes mellitus with diabetic autonomic (poly)neuropathy. This diagnosis is part of the broader classification of diabetes mellitus and specifically addresses complications arising from the disease. Understanding the criteria for diagnosing this condition involves recognizing the symptoms, clinical findings, and the diagnostic process.

Understanding Diabetic Autonomic Neuropathy

Diabetic autonomic neuropathy is a type of nerve damage that affects the autonomic nervous system, which controls involuntary bodily functions such as heart rate, blood pressure, digestion, and bladder function. This condition is a common complication of diabetes, particularly Type 2 diabetes, and can lead to significant morbidity if not properly managed.

Diagnostic Criteria

  1. Diagnosis of Type 2 Diabetes Mellitus:
    - The first step in diagnosing E11.43 is confirming the presence of Type 2 diabetes mellitus. This is typically done through:

    • Fasting plasma glucose levels of 126 mg/dL (7.0 mmol/L) or higher.
    • A 2-hour plasma glucose level of 200 mg/dL (11.1 mmol/L) or higher during an oral glucose tolerance test.
    • A hemoglobin A1c (HbA1c) level of 6.5% or higher.
    • Symptoms of hyperglycemia (e.g., polyuria, polydipsia) in conjunction with a random plasma glucose level of 200 mg/dL (11.1 mmol/L) or higher[1][2].
  2. Symptoms of Autonomic Neuropathy:
    - Patients may present with various symptoms indicative of autonomic dysfunction, including:

    • Orthostatic hypotension (drop in blood pressure upon standing).
    • Gastrointestinal issues such as gastroparesis (delayed gastric emptying), diarrhea, or constipation.
    • Bladder dysfunction, including urinary retention or incontinence.
    • Sexual dysfunction, particularly erectile dysfunction in men and decreased libido in women[3][4].
  3. Clinical Evaluation:
    - A thorough clinical evaluation is essential. This may include:

    • Neurological examinations to assess autonomic function.
    • Heart rate variability tests to evaluate cardiovascular autonomic function.
    • Quantitative sensory testing to assess sensory nerve function[5].
  4. Exclusion of Other Causes:
    - It is crucial to rule out other potential causes of neuropathy, such as vitamin deficiencies, alcohol use, and other systemic diseases (e.g., hypothyroidism, renal failure) that could contribute to similar symptoms[6].

  5. Diagnostic Testing:
    - Additional tests may be performed to confirm the diagnosis and assess the extent of nerve damage, including:

    • Nerve conduction studies (NCS) to evaluate the electrical conduction of nerves.
    • Electromyography (EMG) to assess the electrical activity of muscles[7].

Documentation and Coding

For proper coding under ICD-10, it is essential that healthcare providers document the diagnosis accurately, including:
- The presence of Type 2 diabetes mellitus.
- Specific symptoms or clinical findings that indicate autonomic neuropathy.
- Any relevant test results that support the diagnosis.

This thorough documentation is critical for appropriate billing and coding, ensuring that the patient's condition is accurately represented in medical records and insurance claims[8][9].

Conclusion

Diagnosing E11.43 involves a comprehensive approach that includes confirming Type 2 diabetes mellitus, identifying symptoms of autonomic neuropathy, conducting clinical evaluations, and performing necessary diagnostic tests. Proper documentation is vital for effective management and reimbursement. If you suspect diabetic autonomic neuropathy in a patient with Type 2 diabetes, a detailed assessment and appropriate coding are essential for optimal care and support.

Treatment Guidelines

The management of Type 2 diabetes mellitus with diabetic autonomic (poly)neuropathy, classified under ICD-10 code E11.43, involves a multifaceted approach aimed at controlling blood glucose levels, alleviating symptoms, and preventing complications. Here’s a detailed overview of standard treatment strategies:

1. Glycemic Control

a. Lifestyle Modifications

  • Dietary Changes: A balanced diet rich in whole grains, lean proteins, healthy fats, and plenty of fruits and vegetables is essential. Patients are often advised to limit refined sugars and carbohydrates to help manage blood glucose levels effectively[1].
  • Physical Activity: Regular exercise can improve insulin sensitivity and help maintain a healthy weight. Aiming for at least 150 minutes of moderate-intensity aerobic activity per week is generally recommended[1][2].

b. Pharmacotherapy

  • Oral Hypoglycemics: Medications such as metformin, sulfonylureas, and SGLT2 inhibitors are commonly prescribed to help lower blood sugar levels. The choice of medication may depend on individual patient factors, including kidney function and cardiovascular health[2][3].
  • Insulin Therapy: In cases where oral medications are insufficient, insulin therapy may be initiated. This can be particularly important for patients with significant hyperglycemia or those who have difficulty managing their diabetes with oral agents alone[3].

2. Management of Neuropathy Symptoms

a. Medications

  • Pain Management: Neuropathic pain can be addressed with medications such as gabapentin, pregabalin, or duloxetine, which are effective in managing nerve pain associated with diabetic neuropathy[4][5].
  • Antidepressants: Certain antidepressants, particularly tricyclics, may also be beneficial for pain relief in neuropathy[4].

b. Non-Pharmacological Approaches

  • Physical Therapy: Engaging in physical therapy can help improve mobility and reduce discomfort associated with neuropathy. Tailored exercise programs can enhance strength and balance, reducing the risk of falls[5].
  • Transcutaneous Electrical Nerve Stimulation (TENS): This therapy may provide relief from neuropathic pain by delivering electrical impulses to the skin, which can help modulate pain signals[5].

3. Monitoring and Preventive Care

a. Regular Check-ups

  • Foot Care: Patients with diabetic neuropathy are at increased risk for foot ulcers and infections. Regular foot examinations and education on proper foot care are crucial to prevent complications[6].
  • Blood Pressure and Lipid Management: Monitoring and managing blood pressure and lipid levels are essential components of diabetes care, as they help reduce the risk of cardiovascular complications associated with diabetes[2][3].

b. Education and Support

  • Diabetes Education: Providing patients with education about their condition, self-monitoring of blood glucose, and the importance of adherence to treatment plans is vital for effective management[6].
  • Support Groups: Encouraging participation in diabetes support groups can help patients cope with the emotional and psychological aspects of living with diabetes and its complications[6].

Conclusion

The treatment of Type 2 diabetes mellitus with diabetic autonomic (poly)neuropathy requires a comprehensive approach that includes lifestyle modifications, pharmacotherapy, symptom management, and regular monitoring. By addressing both glycemic control and the specific symptoms of neuropathy, healthcare providers can significantly improve the quality of life for patients affected by this condition. Continuous education and support are also critical in empowering patients to manage their diabetes effectively and prevent complications.

For further information or personalized treatment plans, patients should consult their healthcare providers, who can tailor interventions based on individual health needs and circumstances.

Description

ICD-10 code E11.43 refers to Type 2 diabetes mellitus with diabetic autonomic (poly)neuropathy. This classification is part of the International Classification of Diseases, 10th Revision (ICD-10), which is used globally for coding and classifying health conditions and diseases.

Clinical Description

Type 2 Diabetes Mellitus

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance and relative insulin deficiency. It is the most common form of diabetes, often associated with obesity, sedentary lifestyle, and genetic predisposition. Patients typically present with symptoms such as increased thirst, frequent urination, fatigue, and blurred vision. Long-term complications can affect various organ systems, including the cardiovascular, renal, and nervous systems[1][2].

Diabetic Autonomic Neuropathy

Diabetic autonomic neuropathy is a type of nerve damage that affects the autonomic nervous system, which controls involuntary bodily functions such as heart rate, blood pressure, digestion, and bladder function. This condition can lead to a variety of symptoms, including:

  • Cardiovascular Issues: Orthostatic hypotension (a drop in blood pressure upon standing), resting tachycardia, and impaired heart rate variability.
  • Gastrointestinal Problems: Gastroparesis (delayed gastric emptying), constipation, or diarrhea.
  • Genitourinary Symptoms: Bladder dysfunction, erectile dysfunction in men, and sexual dysfunction in women.
  • Sweating Abnormalities: Either excessive sweating or reduced sweating, leading to heat intolerance[3][4].

Polyneuropathy

Polyneuropathy refers to damage to multiple peripheral nerves, which can result in symptoms such as pain, tingling, numbness, and weakness, primarily in the extremities. In the context of diabetes, this condition is often a result of prolonged hyperglycemia, leading to nerve damage due to metabolic and vascular factors. Patients may experience sensory loss, which can increase the risk of foot ulcers and infections[5][6].

Diagnostic Criteria

To diagnose E11.43, healthcare providers typically consider:

  • Clinical History: A confirmed diagnosis of Type 2 diabetes mellitus, often supported by laboratory tests showing elevated blood glucose levels.
  • Neurological Assessment: Evaluation of symptoms consistent with autonomic dysfunction, including cardiovascular, gastrointestinal, and genitourinary symptoms.
  • Electrophysiological Studies: Nerve conduction studies may be performed to assess the extent of nerve damage and confirm the diagnosis of neuropathy[7].

Management and Treatment

Management of E11.43 involves a multidisciplinary approach, focusing on:

  • Glycemic Control: Tight control of blood glucose levels through lifestyle modifications, oral hypoglycemic agents, or insulin therapy to prevent further nerve damage.
  • Symptomatic Treatment: Addressing specific symptoms of autonomic neuropathy, such as medications for gastroparesis or cardiovascular issues.
  • Regular Monitoring: Routine foot examinations and neurological assessments to detect complications early and prevent severe outcomes[8][9].

Conclusion

ICD-10 code E11.43 encapsulates the complexities of managing Type 2 diabetes mellitus with diabetic autonomic (poly)neuropathy. Understanding the clinical implications and management strategies is crucial for healthcare providers to improve patient outcomes and quality of life. Regular monitoring and comprehensive care are essential in mitigating the risks associated with this condition, emphasizing the importance of early detection and intervention.

For further information on coding and documentation related to diabetes and its complications, healthcare professionals can refer to resources such as the Coding Tip Sheet for Diabetes Mellitus and the Documentation and Coding for Diabetes guidelines[10].

Clinical Information

The ICD-10 code E11.43 refers to Type 2 diabetes mellitus with diabetic autonomic (poly)neuropathy. This condition is characterized by a range of clinical presentations, signs, symptoms, and patient characteristics that are important for diagnosis and management. Below is a detailed overview of these aspects.

Clinical Presentation

Overview of Type 2 Diabetes Mellitus

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance and relative insulin deficiency. It often leads to various complications, including neuropathy, which can affect both the peripheral and autonomic nervous systems. Diabetic autonomic neuropathy (DAN) specifically refers to the impairment of autonomic nerves, which control involuntary bodily functions.

Signs and Symptoms of Diabetic Autonomic Neuropathy

Patients with E11.43 may exhibit a variety of symptoms related to autonomic dysfunction, including:

  • Cardiovascular Symptoms: Orthostatic hypotension (a drop in blood pressure upon standing), resting tachycardia, and impaired heart rate variability.
  • Gastrointestinal Symptoms: Gastroparesis (delayed gastric emptying), constipation, diarrhea, and dysphagia (difficulty swallowing).
  • Genitourinary Symptoms: Erectile dysfunction in men, urinary incontinence, and bladder dysfunction.
  • Sweating Abnormalities: Anhidrosis (lack of sweating) or hyperhidrosis (excessive sweating), which can lead to temperature regulation issues.
  • Pupillary Changes: Difficulty with accommodation (the ability to focus on near objects) and changes in pupil size.

Other Common Symptoms of Type 2 Diabetes

In addition to autonomic symptoms, patients may also experience general symptoms of diabetes, such as:

  • Increased thirst (polydipsia)
  • Frequent urination (polyuria)
  • Increased hunger (polyphagia)
  • Fatigue
  • Blurred vision
  • Slow-healing sores or frequent infections

Patient Characteristics

Demographics

  • Age: T2DM typically occurs in adults, but increasing rates are observed in adolescents and children due to rising obesity rates.
  • Obesity: A significant proportion of patients with T2DM are overweight or obese, which is a major risk factor for the development of the disease and its complications.
  • Family History: A family history of diabetes can increase the risk of developing T2DM and its complications.

Risk Factors

  • Sedentary Lifestyle: Physical inactivity contributes to obesity and insulin resistance.
  • Diet: High-calorie diets rich in sugars and fats can lead to weight gain and metabolic syndrome.
  • Hypertension and Dyslipidemia: Many patients with T2DM also have high blood pressure and abnormal lipid levels, which can exacerbate complications.

Comorbid Conditions

Patients with E11.43 often have other comorbidities, including:
- Cardiovascular disease
- Chronic kidney disease
- Peripheral artery disease
- Other forms of neuropathy

Diagnosis and Evaluation

Diagnostic Criteria

The diagnosis of diabetic autonomic neuropathy is typically based on clinical evaluation and may include:
- Symptom Assessment: Detailed patient history focusing on autonomic symptoms.
- Physical Examination: Assessment of blood pressure changes, heart rate variability, and gastrointestinal function.
- Diagnostic Tests: Tests such as the tilt table test for orthostatic hypotension, gastric emptying studies for gastroparesis, and urodynamic studies for bladder function.

Importance of Early Detection

Early identification of diabetic autonomic neuropathy is crucial, as it can significantly impact the quality of life and increase the risk of other complications. Management strategies often include glycemic control, lifestyle modifications, and symptomatic treatment.

Conclusion

ICD-10 code E11.43 encapsulates a significant complication of Type 2 diabetes mellitus, highlighting the importance of recognizing the clinical presentation, signs, symptoms, and patient characteristics associated with diabetic autonomic neuropathy. Effective management requires a comprehensive approach that addresses both the diabetes itself and its complications, ensuring better patient outcomes and quality of life. Regular monitoring and proactive care are essential in managing this complex condition.

Related Information

Approximate Synonyms

  • Type 2 Diabetes with Autonomic Neuropathy
  • Diabetic Autonomic Neuropathy (DAN)
  • Diabetic Polyneuropathy
  • Diabetes Mellitus with Autonomic Dysfunction
  • Type 2 Diabetes with Nerve Damage

Diagnostic Criteria

  • Diagnosis of Type 2 Diabetes Mellitus
  • Fasting plasma glucose >126 mg/dL
  • 2-hour plasma glucose >200 mg/dL
  • HbA1c level >6.5%
  • Symptoms of hyperglycemia with random plasma glucose >200 mg/dL
  • Orthostatic hypotension
  • Gastrointestinal issues (gastroparesis, diarrhea, constipation)
  • Bladder dysfunction (urinary retention or incontinence)
  • Sexual dysfunction (erectile dysfunction, decreased libido)
  • Neurological examination for autonomic function
  • Heart rate variability test
  • Quantitative sensory testing
  • Exclusion of other causes (vitamin deficiencies, alcohol use, systemic diseases)
  • Nerve conduction studies (NCS) and electromyography (EMG)

Treatment Guidelines

  • Dietary Changes: Balanced diet with whole grains
  • Physical Activity: 150 minutes of moderate exercise
  • Oral Hypoglycemics: Metformin, Sulfonylureas, SGLT2 inhibitors
  • Insulin Therapy: For significant hyperglycemia or oral agent failure
  • Pain Management: Gabapentin, Pregabalin, Duloxetine
  • Foot Care: Regular examinations and education
  • Blood Pressure Management: Regular monitoring and control

Description

Clinical Information

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