Discuss This Drug

palbociclib

CHEBI:CHEBI_85993

Definition

A member of the class of pyridopyrimidines that is 2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}pyrido[2,3-d]pyrimidin-7-one bearing additional methyl, acetyl and cyclopentyl substituents at positions 5, 6 and 8 respectively. It is used in combination with letrozole for the treatment of metastatic breast cancer.

Chemical Information

Molecular Formula
C24H29N7O2
Molecular Mass
447.53280
Charge
0
SMILES
CC(=O)c1c(C)c2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n(C2CCCC2)c1=O
InChI
InChI=1S/C24H29N7O2/c1-15-19-14-27-24(28-20-8-7-18(13-26-20)30-11-9-25-10-12-30)29-22(19)31(17-5-3-4-6-17)23(33)21(15)16(2)32/h7-8,13-14,17,25H,3-6,9-12H2,1-2H3,(H,26,27,28,29)
InChIKey
AHJRHEGDXFFMBM-UHFFFAOYSA-N

Alternative Names

  • 6-Acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-ylpyridin-2-ylamino)-8H-pyrido(2,3-d)pyrimidin-7-one
  • 6-acetyl-8-cyclopentyl-5-methyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one
  • IBRANCE
  • palbociclib
  • PD 0332991
  • PD 332991
  • PD-0332991
  • PD0332991
  • UNII-G9ZF61LE7G

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
1601374
oboInOwl#hasDbXref
Wikipedia:Palbociclib
core#notation
CHEBI:85993

Additional References

Wikipedia:Palbociclib

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
1601374
oboInOwl#hasDbXref
Wikipedia:Palbociclib
oboInOwl#id
CHEBI:85993
core#notation
CHEBI:85993
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_82665
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
has_treatment
http://purl.obolibrary.org/obo/DOID_5746
rdf-schema#range
https://w3id.org/def/predibionto#has_drug_112629
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect37242
owl#annotatedSource
t310892
owl#someValuesFrom
t3499902